CAJ | 학술논문

目的探讨阿托伐他汀对老年卒中患者动脉粥样硬化斑块及预后的影响.方法 124例脑卒中患者随机分为两组,观察组64例在常规治疗基础上加用阿托伐他汀20 mg,对照组60例给予常规基础治疗.比较两组治疗后卒中复发率,血脂水平及治疗后患者生活能力情况.结果 (1)治疗组复发率为4.7％,对照组为18.3％(x2=5.76,P＜0.05).两组不良反应发生率差异无统计学意义(x2=0.00,P＞0.05).(2)治疗组治疗后与治疗前比较,治疗组治疗后与对照组治疗后比较,总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白-胆固醇(LDL-C)及高密度脂蛋白-胆固醇(HDL-C)水平比较差异均有统计学意义(均P＜0.05).(3)治疗后治疗组生活能力显著好于对照组(x2 =24.18,P＜0.05).结论单独应用阿伐他汀能够有效降低缺血性脑卒中患者的血脂水平,改善患者预后、提高患者生活能力及降低卒中发生率,且安全性好.
목적 탐토아탁벌타정대노년졸중환자동맥죽양경화반괴급예후적영향.방법 124례뇌졸중환자수궤분위량조,관찰조64례재상규치료기출상가용아탁벌타정20 mg,대조조60례급여상규기출치료.비교량조치료후졸중복발솔,혈지수평급치료후환자생활능력정황.결과 (1)치료조복발솔위4.7％,대조조위18.3％(x2=5.76,P＜0.05).량조불량반응발생솔차이무통계학의의(x2=0.00,P＞0.05).(2)치료조치료후여치료전비교,치료조치료후여대조조치료후비교,총담고순(TC)、삼선감유(TG)、저밀도지단백-담고순(LDL-C)급고밀도지단백-담고순(HDL-C)수평비교차이균유통계학의의(균P＜0.05).(3)치료후치료조생활능력현저호우대조조(x2 =24.18,P＜0.05).결론 단독응용아벌타정능구유효강저결혈성뇌졸중환자적혈지수평,개선환자예후、제고환자생활능력급강저졸중발생솔,차안전성호.
Objective To explore the influence of atorvastatin on the carotid atherosclerotic plaque and prognosis of older apoplexy.Methods 124 patients with carotid atherosclerotic plaque were randomly divided into 2groups,64 cases in the observetion group who had given atorvastatin(20mg) and general,and 60 cases in control group who had given genenal treatment.The relapse rate of apoplexy,the level of blood-fat and live viability condition were compared.Results ( 1 ) In the treatment group,the recurrence rate was 4.7％,and 18.3 ％ in the control group,the difference was statistically significant(x2=5.76,P ＜ 0.05 ).The two groups of adverse events had no significant difference ( x2=0.00,P ＞ 0.05 ).(2) In the treatment group,after treatment compared with before treatment,after the treatment group compared with the control group after treatment,TC,TG,LDL-C,HDL-C levels were statistically different ( all P ＜　0.05 ).(3) The life skills of the treatment group after treatment was signiflcantly better than the control group,the difference was statistically significant( x2 =24.18,P ＜ 0.05 ).Conclusion A torvastatin could significantly reduce the level of blood fat,improve prognosis,and reduce the rate of apoplexy,and had good effect.