CAJ | 학술논문

目的研究胃癌组织中巨噬细胞抑制细胞因子-1(MIC-1)蛋白的表达特点和意义.方法常规石蜡包埋行MIC-1免疫组织化学染色.结果 MIC-1在Ⅲ/Ⅳ期、癌细胞侵润浆膜层和淋巴结转移的胃癌组织中的阳性表达明显高于Ⅰ/Ⅱ期、癌细胞未侵润至浆膜层和淋巴结未转移的胃癌组织,组间比较差异均有显著性(P＜0.01);复发组与非复发组胃癌组织MIC-1的表达之间存在差异(P＜0.01).结论 MIC-1表达与胃癌的发生发展、生物学行为和预后可能有关,可作为重要的生物学标记物.
목적 연구위암조직중거서세포억제세포인자-1(MIC-1)단백적표체특점화의의.방법 상규석사포매행MIC-1면역조직화학염색.결과 MIC-1재Ⅲ/Ⅳ기、암세포침윤장막층화림파결전이적위암조직중적양성표체명현고우Ⅰ/Ⅱ기、암세포미침윤지장막층화림파결미전이적위암조직,조간비교차이균유현저성(P＜0.01);복발조여비복발조위암조직MIC-1적표체지간존재차이(P＜0.01).결론 MIC-1표체여위암적발생발전、생물학행위화예후가능유관,가작위중요적생물학표기물.
Objective To examine the expression macrophage inhibitory cytokine-1 (MIC-1) in gastric cancer tissue and its biological significance. Methods MIC-1 was detected by immunohistochemical method of strept audin-biotin complex in formalin-fixed specimens of 70 gastric cancer patients. Results The positive expression rates of MIC-1 were significantly higher in the tissues of advanced TNM staging、with infiltration into serous layer and with lymphnode metastasis than that of early TNM staging、without infiltration into serous layer and without lymphnode metastasis. The MIC-1 expression is much higher in recurrent gastric carcinoma than that in non-recurrent(P ＜0. 01). Conclusion MIC-1 nay be associated with the carcinogenesis、biological behaviors and prognosis of gastric cancer. This factor may be used as important biological markers in gastric cancer.