CAJ | 학술논문

目的探讨二甲双胍对冠心病患者代谢综合征的影响.方法 52例冠心病合并代谢综合征(MS)患者随机分为对照组20例和观察组32例,分别采用冠心病标准治疗以及在此基础上加用二甲双胍治疗,追踪时间为1年.对两组治疗前后的空腹血糖(FPG)、餐后2 h血糖、空腹胰岛素(FINS)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、胰岛素抵抗指数(IRI)等指标进行比较,同时比较治疗后两组之间上述指标以及心血管事件发生率.结果与对照组比较,观察组患者治疗后FPG、餐后2 h血糖、FINS、TG、IRI均明显下降(P<0.05),其心血管事件发生率也明显低于对照组(P<0.05).结论二甲双胍能降低冠心病合并MS患者的血糖、TG、BMI和FINS,改善胰岛素敏感度,全面控制心血管危险因素,保护心血管免受损害,减少心血管事件的发生率,使患者多方获益.
목적 탐토이갑쌍고대관심병환자대사종합정적영향.방법 52례관심병합병대사종합정(MS)환자수궤분위대조조20례화관찰조32례,분별채용관심병표준치료이급재차기출상가용이갑쌍고치료,추종시간위1년.대량조치료전후적공복혈당(FPG)、찬후2 h혈당、공복이도소(FINS)、감유삼지(TG)、총담고순(TC)、고밀도지단백-담고순(HDL-C)、이도소저항지수(IRI)등지표진행비교,동시비교치료후량조지간상술지표이급심혈관사건발생솔.결과 여대조조비교,관찰조환자치료후FPG、찬후2 h혈당、FINS、TG、IRI균명현하강(P<0.05),기심혈관사건발생솔야명현저우대조조(P<0.05).결론 이갑쌍고능강저관심병합병MS환자적혈당、TG、BMI화FINS,개선이도소민감도,전면공제심혈관위험인소,보호심혈관면수손해,감소심혈관사건적발생솔,사환자다방획익.
Objective To investigate the influence of metformin on metabolic syndrome in patients with coronary artery disease.Methods 52 patients with coronary artery disease and metabolic syndrome were randomly assigned into 2 groups.the control group with 20 cases and the study group with 32 cases.All the patients were treated with standard coronary artery disease therapy and meanwhile the study group was administered with metformin in addition to the basic therapy above.The follow-up time is one year.FPG,2h postprandial glucose,FINS,TG,TC,HDL-C,insulin resistance index and other standards were compared before and after the therapy,and between the 2 groups when the observation was finished.The rate of cardiovascular events was also compared between the 2 groups.Results Compared with the control group,the study group had lower levels of FPG,2h postprandial glucose,FINS,TG and insulin resistance index when the therapy was completed(P<0.05),and the rate of cardiovascular events was also lower(P<0.05).Conclusion Metformin could lower the levels of glucose,FINS,BMI,TG and insulin resistance index in patients with coronary artery disease and metabolic syndrome.Thus,it could reduce and undermine cardlovascular risk factors,protect the cardiovascular system,reduce the rate of cardiovascular events,which fully benefits the patients.