中国医药
中國醫藥
중국의약
CHINA MEDICINE
2009年
1期
16-17
,共2页
潘兴寿%李天资%陆克兴%蓝景生%黄照河%黄显南%谭志辉%潘征
潘興壽%李天資%陸剋興%藍景生%黃照河%黃顯南%譚誌輝%潘徵
반흥수%리천자%륙극흥%람경생%황조하%황현남%담지휘%반정
高血压%胰岛素%血脂
高血壓%胰島素%血脂
고혈압%이도소%혈지
Hypertension%Insulin%Blood-lipid
目的 探讨高血压病患者胰岛素水平变化与血脂的协同关系.方法 选取单纯高血压病患者(高血压组)、高血压伴代谢综合征患者(高血压伴代谢综合征组)和健康体检者(对照组)各40例,测血压及血清胆固醇(TC)、甘油三酯(TG)和空腹胰岛素.用单因素方差分析判定各组间参数差异的统计学意义,用多因素方差分析血脂、胰岛素与高血压的相互影响情况.结果 高血压组TC(6.27±1.24)mmol/L、TG(2.34±1.25)mmol/L,高血压伴代谢综合征组TC(6.28±1.36)mmol/L、TG(2.69±1.32)mmol/L,2组与对照组TC(5.49±1.06)mmol/L与TG(1.17±0.50)mmol/L比较,差异均有统计学意义(均P＜0.01);3组空腹胰岛素分别为(16.42±5.38)、(21.47±5.73)和(28.05±7.32)mU/L,高血压伴代谢综合征组与对照组比较,差异有统计学意义(P＜0.01);多因素方差分析结果显示,单纯的血脂及单纯的胰岛素水平增高与高血压无明显相关(P＞0.05),仅在血脂和胰岛素两者都增高时,与高血压有明显相关(P＜0.01).结论 血脂、胰岛素两者都增高时与高血压之间存在着明显的协同关系.
目的 探討高血壓病患者胰島素水平變化與血脂的協同關繫.方法 選取單純高血壓病患者(高血壓組)、高血壓伴代謝綜閤徵患者(高血壓伴代謝綜閤徵組)和健康體檢者(對照組)各40例,測血壓及血清膽固醇(TC)、甘油三酯(TG)和空腹胰島素.用單因素方差分析判定各組間參數差異的統計學意義,用多因素方差分析血脂、胰島素與高血壓的相互影響情況.結果 高血壓組TC(6.27±1.24)mmol/L、TG(2.34±1.25)mmol/L,高血壓伴代謝綜閤徵組TC(6.28±1.36)mmol/L、TG(2.69±1.32)mmol/L,2組與對照組TC(5.49±1.06)mmol/L與TG(1.17±0.50)mmol/L比較,差異均有統計學意義(均P＜0.01);3組空腹胰島素分彆為(16.42±5.38)、(21.47±5.73)和(28.05±7.32)mU/L,高血壓伴代謝綜閤徵組與對照組比較,差異有統計學意義(P＜0.01);多因素方差分析結果顯示,單純的血脂及單純的胰島素水平增高與高血壓無明顯相關(P＞0.05),僅在血脂和胰島素兩者都增高時,與高血壓有明顯相關(P＜0.01).結論 血脂、胰島素兩者都增高時與高血壓之間存在著明顯的協同關繫.
목적 탐토고혈압병환자이도소수평변화여혈지적협동관계.방법 선취단순고혈압병환자(고혈압조)、고혈압반대사종합정환자(고혈압반대사종합정조)화건강체검자(대조조)각40례,측혈압급혈청담고순(TC)、감유삼지(TG)화공복이도소.용단인소방차분석판정각조간삼수차이적통계학의의,용다인소방차분석혈지、이도소여고혈압적상호영향정황.결과 고혈압조TC(6.27±1.24)mmol/L、TG(2.34±1.25)mmol/L,고혈압반대사종합정조TC(6.28±1.36)mmol/L、TG(2.69±1.32)mmol/L,2조여대조조TC(5.49±1.06)mmol/L여TG(1.17±0.50)mmol/L비교,차이균유통계학의의(균P＜0.01);3조공복이도소분별위(16.42±5.38)、(21.47±5.73)화(28.05±7.32)mU/L,고혈압반대사종합정조여대조조비교,차이유통계학의의(P＜0.01);다인소방차분석결과현시,단순적혈지급단순적이도소수평증고여고혈압무명현상관(P＞0.05),부재혈지화이도소량자도증고시,여고혈압유명현상관(P＜0.01).결론 혈지、이도소량자도증고시여고혈압지간존재착명현적협동관계.
Objective To investigate the relationship between insulin change and blood-lipid in hypertension.Methods Forty lone hypertensive,40 hypertension concomitant with metabolic syndrome and 40 healthy persons(control group)were enrolled in this study.Blood pressure was measured.Blood samples were drawn in an empty stomach,and both insulin and lipid were determined between 8am and 9 am.Mutual effects among blood-lipid,insulin and hypertension were analyzed with multi-way ANOVA.Results Lone hypertension group showed that TC was 6.27±1.24 and TG was 2.34±1.25.Hypertensive concomittant with metabolic syndrome group showed thal TC was 6.28±1.36 and TG was 2.69±1.32 respectively.Compare with control group,both groups showed statistical significance(P＜0.01).FINS of the three groups were 16.42±5.38,21.47±5.73 and 28.05±7.32 respectivly,showing no significant difference(P＞0.05).Multifaetor ANOVA showed no very seriously effects on hypertension if either blood-lipid increase or insulin increased,but side effects occurred if blood.1ipid increase with insulin(P＜0.01).Conclusion There is insulin resistance and disturbance of lipid metabolism in hypertensive,and there is also correlation among simplex blood-lipid,insulin change and hypertensive compound with metabolic syndrome.
