碘摄入量对血清甲状腺球蛋白的影响——5年流行病学随访研究
전섭입량대혈청갑상선구단백적영향——5년류행병학수방연구
Effect of iodine intake on serum thyroglobulin——A five-year prospective epidemiological study
  • 万方数据
    中华内分泌代谢杂志 중화내분비대사잡지
    CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
    2009年 3期 260-263 ,共4页

    史晓光%崇巍%单忠艳%滕晓春%滕笛%关海霞%李玉姝%金迎%于晓会%范晨玲%杨帆%戴红%于扬%李佳%陈彦彦%赵冬%胡凤楠%毛金媛%谷晓岚%杨榕%佟雅洁%王微波%高天舒%李晨阳%滕卫平

    사효광%숭외%단충염%등효춘%등적%관해하%리옥주%금영%우효회%범신령%양범%대홍%우양%리가%진언언%조동%호봉남%모금원%곡효람%양용%동아길%왕미파%고천서%리신양%등위평

    碘%甲状腺球蛋白%前瞻性流行病学研究 碘%甲狀腺毬蛋白%前瞻性流行病學研究
    전%갑상선구단백%전첨성류행병학연구
    Iodine%Thyroglobulin%Prospective epiderniological studies
    目的 观察碘摄入量对血清甲状腺球蛋白(Tg)水平的影响.方法 对1999年盘山(轻度碘缺乏地区)、彰武(碘超足量地区)和黄骅(碘过量地区)血清Tg水平正常的3 099人进行随访,将2004年随访到的2 448人作为研究人群.测定Tg、甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPOAb)、促甲状腺素(TSH)、甲状腺容积,并询问甲状腺疾病的家族史和个人史.分析Tg的影响因素.结果 1999年初访时,不同碘摄入地区Tg水平差异显著[盘山7.5(4.4～13.1)μg/L、黄骅6.8(3.6～11.2)μg/L彰武5.9(3.2～10.7)μg/L,P<0.01];年龄、性别、TgAb阳性、甲状腺肿大、TSH异< 凹鬃聪偌膊「鋈耸范訲g水平的影响亦显著.为排除混杂因素的影响,对TgAb、甲状腺容积、TSH、甲状腺疾病个人史均无异常的1 856人的随访数据进行分析,其初访及随访的Tg水平均有显著地区差异,轻度碘缺乏以及碘过量地区都显著高于碘超足量地区.三地区随访时Tg水平均显著升高,且增加值(△Tg)存在显著地区差异[盘山3.1(-0.2～8.0)μg/L、黄骅3.5(0.5～9.0)μg/L/35彰武2.5(0.3～6.1)μg/L,P<0.01];碘摄入量、初访时的Tg水平、TSH水平及年龄为ATg的独立影响因素.结论 碘摄入量显著影响血清Tg水平,当用血清Tg水平来估计地区碘摄入水平及其变化时,应该同时考虑年龄及TSH等因素.
    목적 관찰전섭입량대혈청갑상선구단백(Tg)수평적영향.방법 대1999년반산(경도전결핍지구)、창무(전초족량지구)화황화(전과량지구)혈청Tg수평정상적3 099인진행수방,장2004년수방도적2 448인작위연구인군.측정Tg、갑상선구단백항체(TgAb)、갑상선과양화물매항체(TPOAb)、촉갑상선소(TSH)、갑상선용적,병순문갑상선질병적가족사화개인사.분석Tg적영향인소.결과 1999년초방시,불동전섭입지구Tg수평차이현저[반산7.5(4.4～13.1)μg/L、황화6.8(3.6～11.2)μg/L창무5.9(3.2～10.7)μg/L,P<0.01];년령、성별、TgAb양성、갑상선종대、TSH이< 요종총야박「옥용범억g수평적영향역현저.위배제혼잡인소적영향,대TgAb、갑상선용적、TSH、갑상선질병개인사균무이상적1 856인적수방수거진행분석,기초방급수방적Tg수평균유현저지구차이,경도전결핍이급전과량지구도현저고우전초족량지구.삼지구수방시Tg수평균현저승고,차증가치(△Tg)존재현저지구차이[반산3.1(-0.2～8.0)μg/L、황화3.5(0.5～9.0)μg/L/35창무2.5(0.3～6.1)μg/L,P<0.01];전섭입량、초방시적Tg수평、TSH수평급년령위ATg적독립영향인소.결론 전섭입량현저영향혈청Tg수평,당용혈청Tg수평래고계지구전섭입수평급기변화시,응해동시고필년령급TSH등인소.
    Objective To clarify the effect of iodine intake on serum thyroglobulin (Tg). Methods A 5-year prospective study was conducted in the 3 different iodine intake areas in China [Panshan (miht deficiency) ,Zhangwu (more than adequate) and Huanghua (excess)]. A total of 3 099 people with normal serum levels of Tg in 1999 were followed and 2 448 of these participants were feasible to be observed in 2004 and included in the present study. The serum levels of Tg, thyraglobulin antibody(TgAb), thyroid peroxidase antibody(TPOAb) and TSH, thyroid volume, family and personal histories of thyroid diseases were measured and inquried. The general linear model (GLM) was used to explore the determinants of Tg. Results Among the study population at baseline, serum Tg were significantly different in three areas [7.5 (4.4-13. 1) μg/L at Panshan, 6.8 (3.6-11.2)μg/L at Huanghua, 5.9 (3.2-10.7) μg/L at Zhangwu, P<0.01]. They were associated with age, sex and the rate of positive TgAb, abnormal thyroid volume, abnormal TSH and positive personal history of thyroid diseases, in order to control the effects of confounding factors, the data from 1856 subjects with thyroid-related indexes all in normal range and without personal history of thyroid diseases were analyzed to clarify the effect of iodine intake on Tg. The serum Tg among three areas were significantly different in both 1999 and 2004, they were all increased in 5 years with significant augment (△ Tg) among the three areas[3.1 (-0.2-8.0) μg/L at Panshan, 3.5 (0.5-9.0)μg/L at Huanghua vs 2. 5(0.3-6.1) μg/L at Zhangwu,P<0.01]. The GLM analysis revealed that age, Tg and TSH levels at baseline were the determinants of △Tg in addition to iodine intake. Conclusion Iodine intake is a dominant determinant of serum Tg. Age and TSH should also be considered while indicating iodine intake by serum Tg.
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