肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2010年
z1期
36-37
,共2页
子宫颈肿瘤%凋亡抑制蛋白质类%Survivin基因%免疫组织化学
子宮頸腫瘤%凋亡抑製蛋白質類%Survivin基因%免疫組織化學
자궁경종류%조망억제단백질류%Survivin기인%면역조직화학
Uterine cervical neoplasms%Inhibitor of apoptosis proteins%Survivin genein%Immunohistochemical method
目的 探讨Survivin的表达及其与子宫颈癌发生、发展的关系.方法 采用免疫组织化学(SP)方法 检测Survivin在40例子宫颈癌组织、38例子宫颈非典型增生组织、10例正常子宫颈组织中的表达情况,并对其与临床病理的关系进行分析.结果 免疫组织化学法测得Survivin在子宫颈癌组织中的阳性表达率[60%(24/60)]高于子宫颈非典型增生[42.1%(16/38)]和正常子官颈组织(0),差异具有统计学意义(P<0.05);Survivin基因的阳性表达率与子宫颈癌的组织学分级和临床分期有关.结论 Survivin可能与子宫颈癌的发生、发展有关.
目的 探討Survivin的錶達及其與子宮頸癌髮生、髮展的關繫.方法 採用免疫組織化學(SP)方法 檢測Survivin在40例子宮頸癌組織、38例子宮頸非典型增生組織、10例正常子宮頸組織中的錶達情況,併對其與臨床病理的關繫進行分析.結果 免疫組織化學法測得Survivin在子宮頸癌組織中的暘性錶達率[60%(24/60)]高于子宮頸非典型增生[42.1%(16/38)]和正常子官頸組織(0),差異具有統計學意義(P<0.05);Survivin基因的暘性錶達率與子宮頸癌的組織學分級和臨床分期有關.結論 Survivin可能與子宮頸癌的髮生、髮展有關.
목적 탐토Survivin적표체급기여자궁경암발생、발전적관계.방법 채용면역조직화학(SP)방법 검측Survivin재40례자궁경암조직、38례자궁경비전형증생조직、10례정상자궁경조직중적표체정황,병대기여림상병리적관계진행분석.결과 면역조직화학법측득Survivin재자궁경암조직중적양성표체솔[60%(24/60)]고우자궁경비전형증생[42.1%(16/38)]화정상자관경조직(0),차이구유통계학의의(P<0.05);Survivin기인적양성표체솔여자궁경암적조직학분급화림상분기유관.결론 Survivin가능여자궁경암적발생、발전유관.
Objective To investigate the expression of Survivin gene and the relationship between Survivin and genesis and development of cervical cancer. Methods The expression of Survivin gene in tissues of 40 patients with cervical cancer, 38 patients with cervical hyperplasia and 10 cases of normal cervical were detected by immunohistochemical SP method, and the relationships between Survivin and the clinical pathological factors were analyzed. Results The expression positive rate of Survivin in cervical cancer tissues (60 %) was significantly higher than that in cervical hyperplasia and normal cervical tissues (42.1 % and 0, respectively), and their differences were statistically significant (P < 0.05). The positive expression rate of Survivin was related with histological grade and the clinical stages of cervical cancer.Conclusion Survivin is related to the genesis and development of cervical cancer.
