CAJ | 학술논문

目的:研究玻璃体腔重复注射曲安奈德(intravitreal triamcinolone,IVTA)治疗视网膜中央静脉阻塞(central retinal vein occlusion,CRVO)引起的黄斑水肿的临床效果.方法:研究对象为17例17眼接受IVTA(4mg)单次及重复注射的CRVO性黄斑水肿患者,均为人工晶状体眼或无晶状体眼(男/女=10/7),重复注射时间均为首次注射后16wk.在术前及术后1,2,3,4mo,分别测量单次注射组和重复注射组最佳矫正视力(best-corrected visual acuity,BCVA)和黄斑中心凹厚度(central foveal thickness,CFT).采用配对-t检验对两组结果进行统计学分析.结果:单次注射组与重复注射组术前BCVA和CFT相比无显著差异.两次注射后BCVA及CFT均有短暂提高,虽然在随访结束时两组的BCVA及CFT与注射前仍有显著差异(单次注射组:P=0.032,0.049,重复注射组:P=0.01,0.008).但重复注射组每个时间点BCVA均显著低于单次注射组(P值分别是0.043,0.011,0.010和0.012).在注射后1,2,3mo,重复注射组CFT均显著高于单次注射组(P值分别是0.040,0.015和0.025).单次及重复注射后眼压最高水平分别是20.0mmHg(SD 2.06)和18.56mmHg(SD 3.65),两者之间无显著性差异(P=0.467).在随访期间未发现其它明显的副作用.结论:在治疗视网膜中央静脉阻塞引起的黄斑水肿时,4mg IVTA重复注射效果要差于单次注射.
목적:연구파리체강중복주사곡안내덕(intravitreal triamcinolone,IVTA)치료시망막중앙정맥조새(central retinal vein occlusion,CRVO)인기적황반수종적림상효과.방법:연구대상위17례17안접수IVTA(4mg)단차급중복주사적CRVO성황반수종환자,균위인공정상체안혹무정상체안(남/녀=10/7),중복주사시간균위수차주사후16wk.재술전급술후1,2,3,4mo,분별측량단차주사조화중복주사조최가교정시력(best-corrected visual acuity,BCVA)화황반중심요후도(central foveal thickness,CFT).채용배대-t검험대량조결과진행통계학분석.결과:단차주사조여중복주사조술전BCVA화CFT상비무현저차이.량차주사후BCVA급CFT균유단잠제고,수연재수방결속시량조적BCVA급CFT여주사전잉유현저차이(단차주사조:P=0.032,0.049,중복주사조:P=0.01,0.008).단중복주사조매개시간점BCVA균현저저우단차주사조(P치분별시0.043,0.011,0.010화0.012).재주사후1,2,3mo,중복주사조CFT균현저고우단차주사조(P치분별시0.040,0.015화0.025).단차급중복주사후안압최고수평분별시20.0mmHg(SD 2.06)화18.56mmHg(SD 3.65),량자지간무현저성차이(P=0.467).재수방기간미발현기타명현적부작용.결론:재치료시망막중앙정맥조새인기적황반수종시,4mg IVTA중복주사효과요차우단차주사.