CAJ | 학술논문

调节性T细胞(Treg)是一类具有独特免疫调节功能的T细胞亚群,可通过多种方式抑制肿瘤免疫,在肿瘤的发生、发展过程中发挥着极为重要的作用.随着对Treg研究的不断深入,越来越多的证据表明Treg通过多种机制参与了肝癌特别是肝细胞肝癌的形成和发展,减少Treg数量能够增强患者的抗肿瘤免疫功能,是肝细胞肝癌预后的独立危险因子;反之,肝癌局部微环境的一些细胞因子能够影响Treg的表型,增强其抑制功能.
조절성T세포(Treg)시일류구유독특면역조절공능적T세포아군,가통과다충방식억제종류면역,재종류적발생、발전과정중발휘착겁위중요적작용.수착대Treg연구적불단심입,월래월다적증거표명Treg통과다충궤제삼여료간암특별시간세포간암적형성화발전,감소Treg수량능구증강환자적항종류면역공능,시간세포간암예후적독립위험인자;반지,간암국부미배경적일사세포인자능구영향Treg적표형,증강기억제공능.
As a functionally unique subset of T cells, regulatory T cells (Treg) suppress tumor immune responses effectively through a variety of mechanisms and play an important role in tumorigenesis and tumor progression. With the deepening research of Treg, There is growing evidence suggests that Treg participate in the formation and development of hepatic tumor, especially hepatocellular carcinoma(HCC). Decreasing the number of Treg could strengthen the antitumor immunity. There fore, the number of Treg is an independent risk factor for HCC prognosis. On the contrary, some cytokines in hepatic tumor microenvironment can affect the phenotype of Treg and enhance their suppressive function.