CAJ | 학술논문

目的探讨烟台市戊型肝炎(HE)流行特征及发病危险因素.方法根据法定传染病报告系统分析烟台市2005-2009年HE疫情资料;采用ELISA检测2028人HE抗体水平,用巢式RT-PCR检测患者粪便,阳性者开展戊肝病毒(HEV)基因测序;采取病例对照研究方法,对HE危险因素进行调查分析.结果烟台市HE呈散在发病,年均发病率为5.70/10万,春季为流行季节,发病年龄以＞40岁中老年人为主,地区分布呈现沿海岸线分布特点,职业以农民较多;血清流行病学调查显示,人群感染率为25.10%;病毒序列分析表明患者的HEV基因型为4型,健康体检HEVIgM阳性者HEV基因为1型.单因素分析显示,食海产贝类、居住环境、不良生活习惯等均为HE发病的危险因素;多因素分析显示,食海产贝类、外出就餐、饮酒、喝生水仍为发病的独立危险因素.结论烟台市HE发病率将维持在较高水平,但不会出现大范围暴发或流行,发病人群仍以农民为主.
목적 탐토연태시무형간염(HE)류행특정급발병위험인소.방법 근거법정전염병보고계통분석연태시2005-2009년HE역정자료;채용ELISA검측2028인HE항체수평,용소식RT-PCR검측환자분편,양성자개전무간병독(HEV)기인측서;채취병례대조연구방법,대HE위험인소진행조사분석.결과 연태시HE정산재발병,년균발병솔위5.70/10만,춘계위류행계절,발병년령이＞40세중노년인위주,지구분포정현연해안선분포특점,직업이농민교다;혈청류행병학조사현시,인군감염솔위25.10%;병독서렬분석표명환자적HEV기인형위4형,건강체검HEVIgM양성자HEV기인위1형.단인소분석현시,식해산패류、거주배경、불량생활습관등균위HE발병적위험인소;다인소분석현시,식해산패류、외출취찬、음주、갈생수잉위발병적독립위험인소.결론 연태시HE발병솔장유지재교고수평,단불회출현대범위폭발혹류행,발병인군잉이농민위주.
Objective To study the prevalent characteristics and risk factors of viral hepatitis E in Yantai and the relative for strategy on viral hepatitis E control in the area. Methods Data on viral hepatitis E incidence reported by the Notifiable Infectious Disease Reporting System in 2005-2009 was analyzed. 2028 persons were chosen for hepatitis E virus (HEV) antibody detection by enzyme linked immunosorbent assay method. RT-nPCR method was applied to obtain the sequence of HEV in HEV cases. A case-control study was used to identify the risk factors of HEV infection.Results The distribution of HEV cases was sporadic in Yantai, and the annual incidence rate was 5.70/100 000, with spring as the prevalent season. Farmers were the main population involved and with those over the age of 40. Regional distribution was mainly along the coastline. Data from the sequential analysis showed that gene type of local patients was type 4 and healthy person whose HEV-IgM was positive was type 1. Finding from the case-control study suggested that eating seafoods,living condition in the households and unhealthy habits played important roles in the infection of HEV.Results from multiple logistic regression showed that eating seafood, with eat-out history, drinking alcohol and un-boiled water were the main risk factors in the infection of HEV. Conclusion The level of HE in Yantai will maintain in a high level, but there is no chance of epidemic outbreak of HE in large range. Population of incidence mainly concentrates on farmers.