CAJ | 학술논문

目的探讨信号转导子和转录激活子5( Signal Transducer and Activators of Transcription 5,STAT5)基因rs2272087位点多态性与哮喘易感性的关系.方法采用聚合酶链反应-直接测序法(polymerase chain reaction sequencing-based typing,PCR-SBT)技术检测哮喘组与对照组STAT5基因rs2272087位点多态性.结果 rs2272087位点基因型频率AA、AG和GG在哮喘组分别为0.600、0.412和0.167,在对照组分别为0.430、0.200和0.367；等位基因A、G频率在哮喘组分别为0.903和0.390,在对照组分别为0.656和0.097；两组的基因型频率及等位基因频率比较差异有统计学意义(x2 =9.40,P＜0.01；x2 =11.58,P＜0.01).结论 STAT5基因rs2272087位点多态性可能是影响哮喘的重要候选基因.
목적 탐토신호전도자화전록격활자5( Signal Transducer and Activators of Transcription 5,STAT5)기인rs2272087위점다태성여효천역감성적관계.방법 채용취합매련반응-직접측서법(polymerase chain reaction sequencing-based typing,PCR-SBT)기술검측효천조여대조조STAT5기인rs2272087위점다태성.결과 rs2272087위점기인형빈솔AA、AG화GG재효천조분별위0.600、0.412화0.167,재대조조분별위0.430、0.200화0.367；등위기인A、G빈솔재효천조분별위0.903화0.390,재대조조분별위0.656화0.097；량조적기인형빈솔급등위기인빈솔비교차이유통계학의의(x2 =9.40,P＜0.01；x2 =11.58,P＜0.01).결론 STAT5기인rs2272087위점다태성가능시영향효천적중요후선기인.
Objective To investigate the correlation rs2272087 polymorphism of STATS gene and asthma.Methods The polymerase chain reaction PCR- SBT technique was used to determine rs2272087 polymorphism in asthma and control group.Results The genotype of AA,AG and GG of rs2272087 were 0.600,0.412 and 0.167 in asthma group,and 0.430,0.200,0.367 in control group,respectively.The frequency of allele A and G was 0.903 and 0.344 in asthma group,and 0.656,0.970 in control group,respectively.There was significant difference in two groups(x2 =9.40,P ＜0.01 ;x2 =11.58,P ＜0.01 ).Conclusions The rs2272087 polymorphism of STAT5 gene may be an important candidate gene for asthma.