国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2012年
2期
116-118
,共3页
王华%黄玲%陈平%钟增铮%许武%赖福娟
王華%黃玲%陳平%鐘增錚%許武%賴福娟
왕화%황령%진평%종증쟁%허무%뢰복연
丹红注射液%急性脑梗死%超敏C-反应蛋白%白细胞介素-6%肿瘤坏死因子-α
丹紅註射液%急性腦梗死%超敏C-反應蛋白%白細胞介素-6%腫瘤壞死因子-α
단홍주사액%급성뇌경사%초민C-반응단백%백세포개소-6%종류배사인자-α
Danhonginjection%Acute cerebral infarction%hs-CRP%IL-6%TNF-α
目的 探讨丹红注射液对急性脑梗死患者神经功能及血清超敏C-反应蛋白( hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的影响.方法 按随机数字表法将80例急性脑梗死患者随机分为两组各40例,均给予阿司匹林、维生素E、维生素C等对症治疗.治疗组在此基础上加用丹红注射液静脉点滴,对照组加用低分子右旋糖苷、胞磷胆碱静脉点滴,均1次/d,14d为1个疗程.结果 治疗后,患者的hs-CRP[治疗组(2.11±0.31) mg/L、对照组(2.72±0.23) mg/L]、TNF-α[治疗组(0.35±0.07) μg/L、对照组(o.51±0.06) μg/L]、IL-6[治疗组(18.17±3.15) pg/ml、对照组(28.13±4.97) pg/ml]均较同组治疗前降低(P＜0.05),治疗组下降程度较对照组更明显.两组患者的日常生活能力(ADL)[治疗组(20.26±2.17)分、对照组(28.83±2.93)分]及卒中量表(NIHSS)评分[治疗组(18.34±1.25)分、对照组(22.52±1.09)分]均较同组治疗前下降(P＜0.05),且治疗组下降更明显.结论 丹红注射液配合对症治疗,可降低急性脑梗死患者血浆TNF-α、hs-CRP、IL-6水平,减轻神经功能缺损程度.
目的 探討丹紅註射液對急性腦梗死患者神經功能及血清超敏C-反應蛋白( hs-CRP)、腫瘤壞死因子-α(TNF-α)、白細胞介素-6(IL-6)的影響.方法 按隨機數字錶法將80例急性腦梗死患者隨機分為兩組各40例,均給予阿司匹林、維生素E、維生素C等對癥治療.治療組在此基礎上加用丹紅註射液靜脈點滴,對照組加用低分子右鏇糖苷、胞燐膽堿靜脈點滴,均1次/d,14d為1箇療程.結果 治療後,患者的hs-CRP[治療組(2.11±0.31) mg/L、對照組(2.72±0.23) mg/L]、TNF-α[治療組(0.35±0.07) μg/L、對照組(o.51±0.06) μg/L]、IL-6[治療組(18.17±3.15) pg/ml、對照組(28.13±4.97) pg/ml]均較同組治療前降低(P＜0.05),治療組下降程度較對照組更明顯.兩組患者的日常生活能力(ADL)[治療組(20.26±2.17)分、對照組(28.83±2.93)分]及卒中量錶(NIHSS)評分[治療組(18.34±1.25)分、對照組(22.52±1.09)分]均較同組治療前下降(P＜0.05),且治療組下降更明顯.結論 丹紅註射液配閤對癥治療,可降低急性腦梗死患者血漿TNF-α、hs-CRP、IL-6水平,減輕神經功能缺損程度.
목적 탐토단홍주사액대급성뇌경사환자신경공능급혈청초민C-반응단백( hs-CRP)、종류배사인자-α(TNF-α)、백세포개소-6(IL-6)적영향.방법 안수궤수자표법장80례급성뇌경사환자수궤분위량조각40례,균급여아사필림、유생소E、유생소C등대증치료.치료조재차기출상가용단홍주사액정맥점적,대조조가용저분자우선당감、포린담감정맥점적,균1차/d,14d위1개료정.결과 치료후,환자적hs-CRP[치료조(2.11±0.31) mg/L、대조조(2.72±0.23) mg/L]、TNF-α[치료조(0.35±0.07) μg/L、대조조(o.51±0.06) μg/L]、IL-6[치료조(18.17±3.15) pg/ml、대조조(28.13±4.97) pg/ml]균교동조치료전강저(P＜0.05),치료조하강정도교대조조경명현.량조환자적일상생활능력(ADL)[치료조(20.26±2.17)분、대조조(28.83±2.93)분]급졸중량표(NIHSS)평분[치료조(18.34±1.25)분、대조조(22.52±1.09)분]균교동조치료전하강(P＜0.05),차치료조하강경명현.결론 단홍주사액배합대증치료,가강저급성뇌경사환자혈장TNF-α、hs-CRP、IL-6수평,감경신경공능결손정도.
Objective To explore the influence of Danhong injection on neurological function and concentration level of high-sensitivity C-reactive protein (hs-CRP),tumor necrosis factor alpha(TNF-α),interleukin 6 (IL-6) in patients with acute cerebral infarction.Methods According to random number table method,eighty patients with acute cerebral infarction were randomly divided into a control group and a treatment gruop.Both groups were treated by aspirin,vitamine E,C and symptomatic treatment.At the same time,the treatment group was added Danhong injection,the control group was added low molecular dextran and citicoline,once a day,for 14 days.Results After the treatment,the concentration levels of hs-CRP [treatment group (2.11 ± 0.31) mg/L,control group (2.72 ± 0.23) mg/L],TNF-α [treatment group (0.35 ± 0.07) μg/L,control group (0.51 ± 0.06) μg/L],IL-6[treatment group (18.17 ± 3.15) pg/ml,control group (28.13 ± 4.97) pg/ml]was significantly lower than those before the treatment in both groups (P＜0.05).However,the concentration level of hs-CRP,TNF-α,IL-6 in treatment group was significantly lower than that in control group (P＜0.05).ADL scores [treatment group (20.26±2.17) scores,control group (28.83 ± 2.93) scores] and NIHSS scores [treatment group (18.34± 1.25) scores,control group s (22.52 ± 1.09) cores] were significantly lower after treatment than those before the treatment in both groups (P＜0.05),but all scores in treatment group were significantly lower than those in control group (P＜0.05).Conclusion Danhong injection decreased the concentration level of hs-CRP,TNF-α,IL-6 and NIHSS scores,ADL scores significantly.It also alleviated neurological function defect,enhanced the patient's activities of daily living,and reduced the disability rate of ischemic brain damage.
