中华内科杂志
中華內科雜誌
중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2010年
6期
469-472
,共4页
朱婕%吴寿岭%王艳秀%王剑利%赵洪涛%侯国盛%李冬青%金成%李金锋%邸艳荣
硃婕%吳壽嶺%王豔秀%王劍利%趙洪濤%侯國盛%李鼕青%金成%李金鋒%邸豔榮
주첩%오수령%왕염수%왕검리%조홍도%후국성%리동청%금성%리금봉%저염영
C反应蛋白%脑出血%病例对照研究
C反應蛋白%腦齣血%病例對照研究
C반응단백%뇌출혈%병례대조연구
C-reactive protein%Cerebral hemorrhage%Case-control study
目的 探讨基线血清高敏C反应蛋白(hs-CRP)水平对新发脑出血风险的预测价值.方法 采用回顾性巢式病例对照研究方法,选择观察队列中新发脑出血患者323例,对照组646例.比较两组组间基线hs-CRP水平,分析不同基线hs-CRP水平对新发脑出血的风险.结果 新发脑出血患者基线hs-CRP水平(1.10 mg/L)高于对照组(0.66 mg/L,P<0.01);hs-CRP四分位数水平较高者(>2.12 mg/L)新发脑出血的风险是较低者(≤0.30 mg/L)的2.58倍(95%CI 1.77～3.76,P<0.01);对hs-CRP以3 mg/L及以第八十百分位点为临界值分组后进行统计分析,hs-CRP与新发脑出血风险的相关性依然存在,OR值分别为2.26(95%CI 1.60～3.20,P<0.01)和2.24(95%CI 1.60～3.13,P<0.01).结论 基线hs-CRP水平对新发脑出血有预测价值,基线hs-CRP水平较高者新发脑出血风险增加.
目的 探討基線血清高敏C反應蛋白(hs-CRP)水平對新髮腦齣血風險的預測價值.方法 採用迴顧性巢式病例對照研究方法,選擇觀察隊列中新髮腦齣血患者323例,對照組646例.比較兩組組間基線hs-CRP水平,分析不同基線hs-CRP水平對新髮腦齣血的風險.結果 新髮腦齣血患者基線hs-CRP水平(1.10 mg/L)高于對照組(0.66 mg/L,P<0.01);hs-CRP四分位數水平較高者(>2.12 mg/L)新髮腦齣血的風險是較低者(≤0.30 mg/L)的2.58倍(95%CI 1.77～3.76,P<0.01);對hs-CRP以3 mg/L及以第八十百分位點為臨界值分組後進行統計分析,hs-CRP與新髮腦齣血風險的相關性依然存在,OR值分彆為2.26(95%CI 1.60～3.20,P<0.01)和2.24(95%CI 1.60～3.13,P<0.01).結論 基線hs-CRP水平對新髮腦齣血有預測價值,基線hs-CRP水平較高者新髮腦齣血風險增加.
목적 탐토기선혈청고민C반응단백(hs-CRP)수평대신발뇌출혈풍험적예측개치.방법 채용회고성소식병례대조연구방법,선택관찰대렬중신발뇌출혈환자323례,대조조646례.비교량조조간기선hs-CRP수평,분석불동기선hs-CRP수평대신발뇌출혈적풍험.결과 신발뇌출혈환자기선hs-CRP수평(1.10 mg/L)고우대조조(0.66 mg/L,P<0.01);hs-CRP사분위수수평교고자(>2.12 mg/L)신발뇌출혈적풍험시교저자(≤0.30 mg/L)적2.58배(95%CI 1.77～3.76,P<0.01);대hs-CRP이3 mg/L급이제팔십백분위점위림계치분조후진행통계분석,hs-CRP여신발뇌출혈풍험적상관성의연존재,OR치분별위2.26(95%CI 1.60～3.20,P<0.01)화2.24(95%CI 1.60～3.13,P<0.01).결론 기선hs-CRP수평대신발뇌출혈유예측개치,기선hs-CRP수평교고자신발뇌출혈풍험증가.
Objective To study the risk prediction for new intracerebral hemorrhage (ICH) with high sensitivity C-reactive protein ( hs-CRP) level. Methods In a retrospective, nested, case-controlled study, 323 cases of ICH were identified and matched with 646 controls. The hs-CRP levels at baseline were compared between the two groups. The relevance of different hs-CRP levels and the risk of ICH were analyzed. Results The ICH group had a higher median hs-CRP levels (1.10 mg/L) as compared with the control group (0. 66 mg/L) with significant difference ( P<0.01 ). In addition, the increase of risk associated with hs-CRP levels was primarily observed in the individuals with the highest quartile of hs-CRP levels(>2.12 mg/L). These patients had an increased risk of ICH (OR 2. 58, 95% CI 1. 77 to 3. 76) as compared with those in the lowest quartile(≤=0.30 mg/L). Individuals with basiline hs-CRP levels above the specified cut point of 3 mg/L ormore and those in the 80th percentile were at a markedly increased risk of ICH (for specified cut point of 3 mg/L,0R2.26, 95% CI 1.60-3.20, P<0.01; for 80th percentile, OR 2.24,95% CI 1.60-3.13, P <0.01, respectively). Conclusions Risk of ICH might be predicted with the level of hs-CRP. With the increase of hs-CRP level at baseline, the risk of ICH was increased.
