CAJ | 학술논문

目的观察肝细胞癌患者经导管动脉化疗栓塞(TAGE)治疗前后MR PWI表现和灌注值的改变.方法回顾性分析经穿刺活检病理证实的肝细胞癌患者28例,在TACE术前和术后3～10 d分别进行MR PWI,得出术前及术后负增强积分(NEI)、病灶达峰值时间(TTP)、最大信号下降斜率(MSD)和信号增强比(SER),采用t检验比较TACE术前与术后上述各指标的差异.结果肝细胞癌瘤区时间信号曲线(TIC)TACE术前呈快速下降,TACE术后趋向平缓;TTP及SER术前分别为(51.2±10.3)s和60.6±36.3,术后分别为(43.7±12.0)s和41.2±27.5,术后较术前降低;NEI值术后为149.6±80.1,术前为108.7±58.9,术后较术前升高,差异均有统计学意义(P＜0.05).MSD值术后较术前降低,但差异无统计学意义(P＞0.05).结论 MR PWI能够敏感地观察到TACE术前后的血流变化,用于评价TACE早期疗效.
목적 관찰간세포암환자경도관동맥화료전새(TAGE)치료전후MR PWI표현화관주치적개변.방법 회고성분석경천자활검병리증실적간세포암환자28례,재TACE술전화술후3～10 d분별진행MR PWI,득출술전급술후부증강적분(NEI)、병조체봉치시간(TTP)、최대신호하강사솔(MSD)화신호증강비(SER),채용t검험비교TACE술전여술후상술각지표적차이.결과 간세포암류구시간신호곡선(TIC)TACE술전정쾌속하강,TACE술후추향평완;TTP급SER술전분별위(51.2±10.3)s화60.6±36.3,술후분별위(43.7±12.0)s화41.2±27.5,술후교술전강저;NEI치술후위149.6±80.1,술전위108.7±58.9,술후교술전승고,차이균유통계학의의(P＜0.05).MSD치술후교술전강저,단차이무통계학의의(P＞0.05).결론 MR PWI능구민감지관찰도TACE술전후적혈류변화,용우평개TACE조기료효.
Objective To investigate the value of MR perfusion imaging in early detection of findings following arterial chemoembolization of hepatocellular carcinoma Methods Twenty eight consecutive patients with pathologically-confirmed HCC were evaluated. All patients underwent MR perfusion imaging at pre-TACE and 3 to 10 days after TACE. The negative enhancement integral (NEI) ,the time to peak(TTP) ,the maximum slope of decrease (MSD) , the signal enhance ratio (SER) were acquired from MRI software FuncTool 2. 5.36a Version. Statistical analysis using SPSS 14, least significant difference test (t test) were utilized. Results The time intensive curve of tumor was observed to descend rapidly to reach the peak at pre-TACE studies, whereas it descended slowly to reach the peak on post TACE studies. The Value of TTP and SER prior to TACE were(51.2 ± 10. 3) s, 60. 6 ± 36. 3 respectively, and post TACE (43.7 ± 12. 0)s, 41.2 ±27. 5 respectively. The values of TTP and SER post TACE were lower than those prior to TACE (P ＜ 0. 05). The value of NEI prior to TACE was 108.7 ± 58.9, and after TACE 149. 6 ±80. 1 and there was statistically significant difference (P ＜0. 05). The Value of MSD post TACE were lower than those prior to TACE, but there was no statistical significance (P ＞ 0. 05). Conclusion PWI is a very sensitive imaging technique that can be used to monitor early dynamic changes of HCC following TACE.