CAJ | 학술논문

目的探讨蚂蚁制剂阴阳平衡散灌肠治疗UC的作用机制.方法溃疡性结肠炎患者82例,其中阴阳平衡散灌肠组(A组)40例和柳氮磺氨吡啶(SASP)栓剂塞肛治疗组(B组)42例,健康对照组35例,用流式细胞仪检测各组外周血及肠黏膜组织中CD+4 CD+25 Tregs细胞的变化.结果治疗前UC患者外周血及肠黏膜组织中的CD+4 CD+25 Tregs细胞数量均显著低于健康对照组(P<0.01),而经SASP和阴阳平衡散灌肠治疗后该细胞亚群明显高于治疗前及对照组(P<0.01或P<0.05).结论 CD+4、CD+25 Tregs细胞亚群在UC的发病及病情转归中可能具有重要免疫调节作用,阴阳平衡散通过调节Tregs细胞的数量对UC发挥治疗作用.
목적 탐토마의제제음양평형산관장치료UC적작용궤제.방법 궤양성결장염환자82례,기중음양평형산관장조(A조)40례화류담광안필정(SASP)전제새항치료조(B조)42례,건강대조조35례,용류식세포의검측각조외주혈급장점막조직중CD+4 CD+25 Tregs세포적변화.결과 치료전UC환자외주혈급장점막조직중적CD+4 CD+25 Tregs세포수량균현저저우건강대조조(P<0.01),이경SASP화음양평형산관장치료후해세포아군명현고우치료전급대조조(P<0.01혹P<0.05).결론 CD+4、CD+25 Tregs세포아군재UC적발병급병정전귀중가능구유중요면역조절작용,음양평형산통과조절Tregs세포적수량대UC발휘치료작용.
Objective To explore the effects and mechanism in patients with ulcerative colitis (UC) treated by Yin Yang equilibrated preparation. Method 82 patients with UC as treatment group and 35 health parsons as control group underwent the testing. The serum and mucosal of all testing persons were taken pre and post treatment to detect CD+4 CD+25 regulatory T cells(Tregs) by flow cytometry at the end of one month,treating with SASP and Yin Yang equilibrated preparation. Result Compared with normal control group,the proportion of CD+4 CD+25 Tregs was markedly decreased in PB and mucesal of group A and B(P <0.01). But it was significanfly increased in therapeutic groups of SASP and Yin Yang equilibrated preparation, and their CD+4 CD+25 Tregs in PB and mucosal were much more than the control group at the end of one month after treating with SASP and Yin Yang equilibrated preparation(P <0.01 or P< 0.05). Conclusion CD+4 CD+25 Tregs with strong immune suppression play a central role in the initia-tion and development of UC,and the Yin Yang equilibrated preparation might exert its therapeutic effects on UC by the regulation of number and function of CD+4 CD+25 Tregs.