CAJ | 학술논문

目的探讨髓芯减压植骨自体骨髓干细胞移植联合中药治疗股骨头坏死(ANFH)的的疗效.方法股骨头坏死患者30例按治疗方法不同分为三组:髓芯减压植骨组(A组)10例,12髋;髓芯减压自体骨髓干细胞移植组(B组)10例,13髋;髓芯减压自体骨髓干细胞移植联合中药组(C组)10例,10髋.观察三组X线平片、CT及M砌检查、Harris评分(HHS)、疗效.结果三组接受治疗的Ⅰ、Ⅱ、Ⅲ期病例,3、6、12个月未出现股骨头变形及塌陷等病情恶化;术后12个月Harriss评分为93分明显高于术前57.5分(X2=5.81,P<0.05);术前MRI检查,测量低信号区所占股骨头体积比为42%.术后股骨头坏死区消失;B、C组总有效率高于A组(X2=3.81,X2=3.98,均P<0.05).结论髓芯减压植骨自体骨髓干细胞移植联合中药治疗股骨头坏死具有损伤小、简便、准确、有效的优点.
목적 탐토수심감압식골자체골수간세포이식연합중약치료고골두배사(ANFH)적적료효.방법 고골두배사환자30례안치료방법불동분위삼조:수심감압식골조(A조)10례,12관;수심감압자체골수간세포이식조(B조)10례,13관;수심감압자체골수간세포이식연합중약조(C조)10례,10관.관찰삼조X선평편、CT급M체검사、Harris평분(HHS)、료효.결과 삼조접수치료적Ⅰ、Ⅱ、Ⅲ기병례,3、6、12개월미출현고골두변형급탑함등병정악화;술후12개월Harriss평분위93분명현고우술전57.5분(X2=5.81,P<0.05);술전MRI검사,측량저신호구소점고골두체적비위42%.술후고골두배사구소실;B、C조총유효솔고우A조(X2=3.81,X2=3.98,균P<0.05).결론수심감압식골자체골수간세포이식연합중약치료고골두배사구유손상소、간편、준학、유효적우점.
Objective To study curative effect of core decompression and autologous bone marrow stem cell transplantation combined with traditional Chinese medicine in the treatment of early femoral head necrosis (ANFH).Methods 30 patients with femoral head necrosis treated by different methods were divided into 3 groups: core decompression A group) 10 cases(12 hips) ;core decompression pus stem cells transplantation(B group) 10 cases(13 hips) ;core decompression pus stem cells transplantation combined with traditional Chinese medicine(C group) 10 ca-ses( 10 hips) ;The X-ray 、CT MRI、Harris score( HHS) .curative effect were observed.Results The phase of Ⅰ,Ⅱ,Ⅲ,in 3 groups didn't appear deformation and collapse at 3,6,12 months;The score of Harris after 12 months 93 points were higher than that preoperatively 57.5 points(χ 2= 5.81 ,P<0.05) ;The signal ratio of femoral head volume in MRI was 42% before treatment,disappearance of femoral head necrosis after treatment;Total curative effect of B,C group,werehighter than that Agroup(χ2 =3.81,χ2 =3.98,P<0.05).Conclusion The operative treatment of ANFH with core decompression and stem cells transplantation combined with traditional Chinese medicine had the advantage of minimal damage,simplicity,accuracy,and effectiveness.