肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2012年
7期
495-497
,共3页
胃肿瘤%PTEN%抑癌基因
胃腫瘤%PTEN%抑癌基因
위종류%PTEN%억암기인
Stomach pcveoplasms%PTEN%Tumor suppressor gene
PTEN是迄今发现的第一个具有双特异性磷酸酶活性的抑癌基因,其主要通过PIP3途径、FAK途径、MAPK途径等发挥其脂质磷酸酶和蛋白磷酸酶活性,诱导细胞凋亡、抑制细胞生长、调节细胞迁移与黏附.PTEN蛋白在胃癌组织中表达下降,提示PTEN基因的异常改变参与了胃黏膜细胞的恶性转化过程,PTEN蛋白表达水平可作为评价胃癌病理生物学行为的客观指标之一.
PTEN是迄今髮現的第一箇具有雙特異性燐痠酶活性的抑癌基因,其主要通過PIP3途徑、FAK途徑、MAPK途徑等髮揮其脂質燐痠酶和蛋白燐痠酶活性,誘導細胞凋亡、抑製細胞生長、調節細胞遷移與黏附.PTEN蛋白在胃癌組織中錶達下降,提示PTEN基因的異常改變參與瞭胃黏膜細胞的噁性轉化過程,PTEN蛋白錶達水平可作為評價胃癌病理生物學行為的客觀指標之一.
PTEN시흘금발현적제일개구유쌍특이성린산매활성적억암기인,기주요통과PIP3도경、FAK도경、MAPK도경등발휘기지질린산매화단백린산매활성,유도세포조망、억제세포생장、조절세포천이여점부.PTEN단백재위암조직중표체하강,제시PTEN기인적이상개변삼여료위점막세포적악성전화과정,PTEN단백표체수평가작위평개위암병리생물학행위적객관지표지일.
PTEN is a tumor suppressor with double specific phosphatase activity,and PTEN brings into its lipid and protein phosphatase activity through PIP3, FAK, MAPK pathway. PTEN also induces apoptosis, inhibits cell growth, and regulates cell migration and adhesiveness. PTEN expression is lower in gastric carcinoma. It may be valuable to evaluate that the abnormal expression of suppressor gene PTEN participates in the malignant conversion process of the gastric mucosa cell, and the expression levels of the PTEN protein can be used to evaluate the pathologic biology behavior of gastric carcinoma.
