CAJ | 학술논문

目的探讨聚焦超声治疗婴幼儿血管瘤的效果及适宜能量参数.方法 80例婴幼儿血管瘤采用区组随机分组法分成4组,每组20例,A、B、C3组采用聚焦超声治疗仪以3～5 mm/s速度连续辐照血管瘤表面,频率9 MHz,脉冲1 000 Hz,重叠10％,扫描5个来回,功率分别为3.5、4.0、4.5W,治疗3次为1个疗程,每次治疗间隔1个月,D组为空白对照组,仅随访观察.观察A、B、C3组治疗结束6个月后效果及辐照区皮肤破溃、瘢痕发生率,并与D组同期结果对照.结果 1个疗程结束6个月后,A、B、C3组分别治愈7、9、8例,基本治愈9、8、10例,好转4、3、2例,总有效率均为100％,D组仅好转5例,经统计学分析,A、B、C3组治疗效果明显好于D组(P＜0.05),但A、B、C3组间治疗效果比较差异无统计学意义(P＞0.05)；B、C组分别有4、6例出现皮肤破溃及瘢痕,经统计学分析B、C组皮肤破溃及瘢痕发生率明显高于A、D组(P<0.05).结论聚焦超声辐照是治疗婴幼儿血管瘤的有效方法之一,能量以不超过3.5W为宜.
목적 탐토취초초성치료영유인혈관류적효과급괄의능량삼수.방법 80례영유인혈관류채용구조수궤분조법분성4조,매조20례,A、B、C3조채용취초초성치료의이3～5 mm/s속도련속복조혈관류표면,빈솔9 MHz,맥충1 000 Hz,중첩10％,소묘5개래회,공솔분별위3.5、4.0、4.5W,치료3차위1개료정,매차치료간격1개월,D조위공백대조조,부수방관찰.관찰A、B、C3조치료결속6개월후효과급복조구피부파궤、반흔발생솔,병여D조동기결과대조.결과 1개료정결속6개월후,A、B、C3조분별치유7、9、8례,기본치유9、8、10례,호전4、3、2례,총유효솔균위100％,D조부호전5례,경통계학분석,A、B、C3조치료효과명현호우D조(P＜0.05),단A、B、C3조간치료효과비교차이무통계학의의(P＞0.05)；B、C조분별유4、6례출현피부파궤급반흔,경통계학분석B、C조피부파궤급반흔발생솔명현고우A、D조(P<0.05).결론 취초초성복조시치료영유인혈관류적유효방법지일,능량이불초과3.5W위의.
Objective To explore the clinical effect and appropriate power of high-intensity focused ultrasound(HIFU) in the treatment of infant hemangioma.Methods 80 infants with hemangioma were randomly divided into four groups,20 cases in each group.All cases in group A,B and C were irradiated on the lesion surface with 3-5 mm/s speed for five continuous come-and-goes using HIFU,with frequency 9 MHz,impulse 1 000 Hz and 10％ scanning overlap.The power was respectively 3.5 W in group A,4.0 W in group B and 4.5 W in group C.One session contained three times of treatment,with one month interval.The cases in group D were only followed up as control group.The therapeutic effect,ulcer and scar in irradiated region in group A,B,C were observed 6 months after the last treatment,which were synchronously compared with those in group D.Results 6 months after the last treatmen,7,9,8cases were cured and 9,8,10 cases were almost cured,and 4,3,2 cases got improved in group A,B,C,respectively.The total effective rate was 100％ in the three groups.While only 5 cases got improved in group D.The treatment effect in group A,B and C was obviously better than that in group D(P ＜0.05),with no significant difference among the three groups statistically (P ＞ 0.05 ).Ulcer and scar in irradiated skin occurred in 0,4,6,0 cases in group A,B,C and D,respectively.The incidence of ulcer and scar was obviously higher in group B and C than that in group A and D statistically ( P < 0.05 ).Conclusions HIFU irradiating is one of effective methods for infant hemangioma treatment.The appropriate power should not be above 3.5 W.