CAJ | 학술논문

目的观察Curosurf即肺表面活性物质(PS)联合机械通气治疗新生儿呼吸窘迫综合征(NRDS)的临床疗效.方法 59例患儿给予PS联合机械通气治疗,同时给予常规治疗,观察肺氧合功能、呼吸机机械通气参数变化及临床效果.结果治疗后患儿血PaO2和pH值升高、PaCO2下降,分别与治疗前比较差异有显著性(P＜0.05);机械通气参数PIP、PEEP渐降低,与治疗前比较差异有显著性(P＜0.05);治疗后54例显效,5例有效,临床总有效率100%.结论应用PS联合机械通气治疗NRDS是安全、有效的,值得临床推广应用.
목적 관찰Curosurf즉폐표면활성물질(PS)연합궤계통기치료신생인호흡군박종합정(NRDS)적림상료효.방법 59례환인급여PS연합궤계통기치료,동시급여상규치료,관찰폐양합공능、호흡궤궤계통기삼수변화급림상효과.결과 치료후환인혈PaO2화pH치승고、PaCO2하강,분별여치료전비교차이유현저성(P＜0.05);궤계통기삼수PIP、PEEP점강저,여치료전비교차이유현저성(P＜0.05);치료후54례현효,5례유효,림상총유효솔100%.결론 응용PS연합궤계통기치료NRDS시안전、유효적,치득림상추엄응용.
Objective To explore the efficacy of Curosurf, a pulmonary surfactant, combined with mechanical ventilation in the treatment of neonatal respiratory distress syndrome (NRDS). Methods 59 neonate patients received Curosurf combined with mechanical entilation plus routine therapy. The ability of lung to oxygenate blood, changes in parameters of mechanical vntilation, and clinical efficacy were observed.Results As compared with the baselines, blood PaO2 level and pH value elevated while PaCO2 level dec lined after treatment, with a significant difference (P＜ 0.05＝; parameters PIP and PEEP gradually decreased, with a significant difference (P＜0.05＝. After treatment, 5 cases of.54 cases got effective, with a total effective rate of 100％. Conclusions The use of Curosurf combined with mechanical ventilation for NRDS is safe, effective, and worth popularizing clinically.