CAJ | 학술논문

目的观察葛根素注射液治疗冠心病心绞痛的临床疗效和安全性.方法选取2009年1月至2011年2月天津市第四中心医院收治的冠心病心绞痛患者388例,随机分为治疗组和对照组各194例,两组患者在常规治疗的基础上,治疗组给予葛根素注射液,对照组给予复方丹参注射液,比较两组的临床疗效、心绞痛发作频率、心肌耗氧指数、心电图变化、血液流变学指标及不良反应.结果治疗组的总有效率(88.14％,171/194)明显高于对照组(61.86％,120/194),两组比较差异有统计学意义(P＜0.05)；与对照组相比,治疗组的心绞痛次数、心肌耗氧指数、ST段下降导联数及压低数值总和、心肌缺血时间、全血黏度低切值、红细胞电泳和红细胞压积明显降低；两组患者在治疗过程中均无明显的不良反应.结论葛根素注射液治疗冠心病心绞痛的疗效确切且安全,具有临床推广使用的意义.
목적 관찰갈근소주사액치료관심병심교통적림상료효화안전성.방법 선취2009년1월지2011년2월천진시제사중심의원수치적관심병심교통환자388례,수궤분위치료조화대조조각194례,량조환자재상규치료적기출상,치료조급여갈근소주사액,대조조급여복방단삼주사액,비교량조적림상료효、심교통발작빈솔、심기모양지수、심전도변화、혈액류변학지표급불량반응.결과 치료조적총유효솔(88.14％,171/194)명현고우대조조(61.86％,120/194),량조비교차이유통계학의의(P＜0.05)；여대조조상비,치료조적심교통차수、심기모양지수、ST단하강도련수급압저수치총화、심기결혈시간、전혈점도저절치、홍세포전영화홍세포압적명현강저；량조환자재치료과정중균무명현적불량반응.결론 갈근소주사액치료관심병심교통적료효학절차안전,구유림상추엄사용적의의.
Objective To observe the clinical efficacy and safety of Puerarin Injection treatment on angina pectoris.Methods 388 patients with angina pectoris,enrolled to Tianjin Fourth Central Hospital during January 2009 and February 2011 were selected and randomly divided into treatment or control groups with 194 patients of each.Based on the conventional therapy program,one group was given Puerarin Injection as treatment group while,the other was given with Danshen Injection as control group.Clinical efficacy,the attack rate of angina pectoris,oxygen consumption,iadices on electrocardiogram,haemorheology and other adverse reactions among the two groups were compared.Results The total efficacy of the treatment group (88.14％,171/194)was significantly higher than the control group (61.86％,120/194) and the difference was statistically significant (P＜0.05).During the treatment,no significant adverse events were noticed in both of the two groups of patients.Conclusion The Puerarin Injection treatment program on angina pectoris seemed effective and safe.