CAJ | 학술논문

目的探讨高容量与常规容量连续性血液净化(CBP)治疗多器官功能障碍综合征(MODS)的疗效.方法选择MODS患者38例,随机分为高容量CBP组(治疗组)18例、常规容量CBP组(对照组)20例,观察并比较两组治疗后24、48 h平均动脉压(MAP)、多巴胺剂量、PaO2/FiO2、APACHEⅡ评分、血乳酸、ICU住院时间、ICU病死率.结果治疗后24、48 h,治疗组MAP、PaO2/FiO2升高,多巴胺剂量、APACHEⅡ评分、血乳酸减少,与对照组比较差异均有统计学意义(均P＜0.05)；与对照组比较,治疗组ICU住院时间缩短[ (8.54±4.15)d与(11.82±5.76)d]、ICU病死率明显降低(22.5％与35.0％)(均P＜0.05).结论高容量连续性血液净化较常规容量连续性血液净化治疗MODS可降低病死率.
목적 탐토고용량여상규용량련속성혈액정화(CBP)치료다기관공능장애종합정(MODS)적료효.방법 선택MODS환자38례,수궤분위고용량CBP조(치료조)18례、상규용량CBP조(대조조)20례,관찰병비교량조치료후24、48 h평균동맥압(MAP)、다파알제량、PaO2/FiO2、APACHEⅡ평분、혈유산、ICU주원시간、ICU병사솔.결과 치료후24、48 h,치료조MAP、PaO2/FiO2승고,다파알제량、APACHEⅡ평분、혈유산감소,여대조조비교차이균유통계학의의(균P＜0.05)；여대조조비교,치료조ICU주원시간축단[ (8.54±4.15)d여(11.82±5.76)d]、ICU병사솔명현강저(22.5％여35.0％)(균P＜0.05).결론 고용량련속성혈액정화교상규용량련속성혈액정화치료MODS가강저병사솔.
Objective To compare the effect of high volume continuous blood purification (CBP) with routine CBP on multiple organ dysfunction syndrome(MODS).Methods 38 patients with MODS were randomly divided into high volume CBP group( treatment group,18 cases) and routine CBP group (control group,20 cases).And they were respectively detected on mean arterial pressure(MAP),dosage of Dopamine,PaO2/FiO2,APACHE [ score,lactic acid,length of stay and mortality in ICU post-treatment 24h and 48h.Results Compared with control group,MAP and PaO2/FiO2 on treatment group were more higher( P ＜ 0.05 ),while dosage of Dopamine,APACHE Ⅱ score,lactic acid were significantly shorter than these of treatment group( P ＜ 0.05 ),and length of stay and mortality in ICU were significantly lower than those of treatmen group [ ( 8.54 ± 4.15 ) d vs ( 11.82 ± 5.76) d,P ＜ 0.05:22.2％ vs 35.0％,P ＜0.05 ].Conclusion High volume CBP could reduce the mortality in ICU compared with control group routine CBP.