中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
15期
6-9
,共4页
胡花%杨晓宁%傅秀芳%顾佳士
鬍花%楊曉寧%傅秀芳%顧佳士
호화%양효저%부수방%고가사
妊娠,异位%血管内皮生长因子类%绒毛膜促性腺激素,β亚单位,人%ROC曲线
妊娠,異位%血管內皮生長因子類%絨毛膜促性腺激素,β亞單位,人%ROC麯線
임신,이위%혈관내피생장인자류%융모막촉성선격소,β아단위,인%ROC곡선
Pregnancy,ectopic%Vascular endothelial growth factors%Chorionic gonadotropin,beta submit,human%ROC curver
目的 探讨血管内皮生长因子(VEGF)联合β-人绒毛膜促性腺激素(β-hCG)早期诊断异位妊娠的价值.方法 分别用双抗体夹心酶联免疫吸附法和放射免疫法测定109例疑似异位妊娠患者的血清VEGF和β-hCG水平,并建立受试者工作特征(ROC)曲线,分析VEGF和β-hCG检测对异位妊娠的诊断价值.结果 109例疑似异位妊娠患者最后确诊异位妊娠62例,宫内妊娠47例.异位妊娠患者血清VEGF水平明显高于宫内妊娠患者(P＜0.05),而β-hCG水平明显低于宫内妊娠患者(P＜0.05).VEGF的ROC曲线下面积为0.87,β-hCG的RO曲线下面积为0.71.以血清VEGF＞140 ng/L诊断异位妊娠,其灵敏度、特异度分别是75.8%(47/62)、80.9%(38/47),以β-hCG＜1200 U/L诊断异位妊娠,其灵敏度、特异度分别是64.5%(40/62)、61.7%(29/47).两者联合检测诊断异位妊娠的灵敏度、特异度分别是80.6%(50/62)、57.4%(27/47).结论 血清VEGF对异位妊娠的早期诊断优于β-hCG,两者联合检测可提高异位妊娠早期诊断率,缩短观察时间.
目的 探討血管內皮生長因子(VEGF)聯閤β-人絨毛膜促性腺激素(β-hCG)早期診斷異位妊娠的價值.方法 分彆用雙抗體夾心酶聯免疫吸附法和放射免疫法測定109例疑似異位妊娠患者的血清VEGF和β-hCG水平,併建立受試者工作特徵(ROC)麯線,分析VEGF和β-hCG檢測對異位妊娠的診斷價值.結果 109例疑似異位妊娠患者最後確診異位妊娠62例,宮內妊娠47例.異位妊娠患者血清VEGF水平明顯高于宮內妊娠患者(P＜0.05),而β-hCG水平明顯低于宮內妊娠患者(P＜0.05).VEGF的ROC麯線下麵積為0.87,β-hCG的RO麯線下麵積為0.71.以血清VEGF＞140 ng/L診斷異位妊娠,其靈敏度、特異度分彆是75.8%(47/62)、80.9%(38/47),以β-hCG＜1200 U/L診斷異位妊娠,其靈敏度、特異度分彆是64.5%(40/62)、61.7%(29/47).兩者聯閤檢測診斷異位妊娠的靈敏度、特異度分彆是80.6%(50/62)、57.4%(27/47).結論 血清VEGF對異位妊娠的早期診斷優于β-hCG,兩者聯閤檢測可提高異位妊娠早期診斷率,縮短觀察時間.
목적 탐토혈관내피생장인자(VEGF)연합β-인융모막촉성선격소(β-hCG)조기진단이위임신적개치.방법 분별용쌍항체협심매련면역흡부법화방사면역법측정109례의사이위임신환자적혈청VEGF화β-hCG수평,병건립수시자공작특정(ROC)곡선,분석VEGF화β-hCG검측대이위임신적진단개치.결과 109례의사이위임신환자최후학진이위임신62례,궁내임신47례.이위임신환자혈청VEGF수평명현고우궁내임신환자(P＜0.05),이β-hCG수평명현저우궁내임신환자(P＜0.05).VEGF적ROC곡선하면적위0.87,β-hCG적RO곡선하면적위0.71.이혈청VEGF＞140 ng/L진단이위임신,기령민도、특이도분별시75.8%(47/62)、80.9%(38/47),이β-hCG＜1200 U/L진단이위임신,기령민도、특이도분별시64.5%(40/62)、61.7%(29/47).량자연합검측진단이위임신적령민도、특이도분별시80.6%(50/62)、57.4%(27/47).결론 혈청VEGF대이위임신적조기진단우우β-hCG,량자연합검측가제고이위임신조기진단솔,축단관찰시간.
Objective To explore the diagnostic values of vascular endothelial growth factor (VEGF) and p -human chorionic gonadotropin( β -hCG) for early ectopic pregnancy. Methods The serum levels of VEGF and β-hCG were measured in 109 patients with suspected ectopic pregnancy by ELISA and RIA respectively, receiver operating characteristic (ROC) curvers were established, the diagnostic values of VEGF and β -hCG for ectopic pregnancy were analyzed. Results One hundred and nine patients with suspected ectopic pregnancy were diagnosed in the end: 62 cases with ectopic pregnancy and 47 cases with intrauterine pregnancy. The levels of VEGF in ectopic pregnancy were significantly higher than those in intrauterine pregnancy (P ＜ 0.05), but the levels of β -hCG were significantly lower than those in intrauterine pregnancy (P ＜ 0.05). The areas under ROC curves of VEGF were 0.87, the areas under ROC curves of β -hCG were 0.71. In VEGF ＞ 140 ng/L for diagnosis of ectopic pregnancy, the sensitivity and specificity were 75.8% (47/62) and 80.9% (38/47) respectively. In β-hCG ＜ 1200 U/L for diagnosis of ectopic pregnancy, the sensitivity and specificity were 64.5%(40/62) and 61.7%(29/47) respectively. The sensitivity and specificity of combined detection of VEGF and β -hCG were 80.6%(50/62) and 57.4%( 27/47) respectively. Conclusions The diagnostic values of VEGF are better than those of β -hCG. The combined detection of VEGF and β -hCG can increase the rate of early diagnosis and shorten observation time.
