CAJ | 학술논문

目的观察胰腺组织移植的远期效果.方法将胚胎胰腺制成1 mm×1mm×1 mm大小的组织块,经培养后移植至胰岛素依赖型糖尿病患者的大网膜及小网膜腔内.结果术后14例患者的胰岛素用量均较术前减少,低血糖出现的时间为术后7～37天.术后5年、6年、7年和8年的胰岛素用量分别为(45.86±16.83)U/d、(46.91±18.34)U/d、(48.60±17.02)U/d和(52.67±14.14)U/d,与术前比较,差异均有显著意义(P<0.01).结论胚胎胰腺组织移植具有一定的远期效果,可作为胰岛素依赖型糖尿病的一种有效的治疗方法;术后效果与移植的胰岛数量、质量及排斥反应有关.
목적 관찰이선조직이식적원기효과.방법 장배태이선제성1 mm×1mm×1 mm대소적조직괴,경배양후이식지이도소의뢰형당뇨병환자적대망막급소망막강내.결과 술후14례환자적이도소용량균교술전감소,저혈당출현적시간위술후7～37천.술후5년、6년、7년화8년적이도소용량분별위(45.86±16.83)U/d、(46.91±18.34)U/d、(48.60±17.02)U/d화(52.67±14.14)U/d,여술전비교,차이균유현저의의(P<0.01).결론 배태이선조직이식구유일정적원기효과,가작위이도소의뢰형당뇨병적일충유효적치료방법;술후효과여이식적이도수량、질량급배척반응유관.
Objective To observe the long-term effects of human fetal pancreatic tissue transplantation.Methods Cultured human fetal pancreatic fragments(1 mm×1 mm×1 mm) were implanted into the greater omentum and omental bursa of 14 patients with insulin-dependent diabetes mellitus(IDDM).Results Postoperative reduction of exogenous insulin requirements was noted in all 14 cases Hypoglycemia appeared in the 7th～37th postoperative days.In the 5th,6th,7th and 8th postoperative years,the required mean regular insulin doses were(45.86±16.83)U/d,(46.91±18.34)U/d,(48.60±17.02)U/d and(52.67±14.14)U/d respectively,which were significantly different from the preoperative ones(P<0.01).Conclusion Fetal pancreatic tissue transplantation has certain long-term effects and could be used as an effective way for treating IDDM.Postoperative efficacy is related to the quantity and quality of islet cells and islet rejection.