中华心血管病杂志
中華心血管病雜誌
중화심혈관병잡지
Chinese Journal of Cardiology
2009年
8期
712-715
,共4页
曹春歌%王红宇%薛文生%韩姬玲%张晓敏
曹春歌%王紅宇%薛文生%韓姬玲%張曉敏
조춘가%왕홍우%설문생%한희령%장효민
血压%年龄因素%动脉僵硬指数
血壓%年齡因素%動脈僵硬指數
혈압%년령인소%동맥강경지수
Blood pressure%Age factors%Arterial stiffness index
目的 动态动脉僵硬指数(AASI)是新近提出的反映收缩压(SBP)和舒张压(DBP)之间动力学关系的一项指标,这项研究的主要目的是探讨正常人AASI随年龄的变化及其与24 h脉压(24 h PP)的相关性.方法 246名正常人[平均年龄(59.7±14.6)岁,女性占38.6%]在保持日常工作和生活起居的情况下配戴24 h动态血压监测(ABPM)仪,记录从早晨6:00到晚上22:00每间隔30min和从晚上22:00到第2天早晨6:00每问隔60 min的血压读数、心率(HR)、平均动脉压(MAP)及脉压(PP),然后按AASI=1-DBP对SBP的回归斜率计算每个个体的AASI值.结果 AASI随年龄的增大而增大.在正常人中,AASI的第95百分位数是0.56,其95%预测区间的上界在20～39岁时为0.49,40～59岁时为0.59,60～79岁时为0.69,≥80岁时为0.79.AASI与24 h PP呈正相关(r=0.497,P＜0.01).在正常人中,AASI随年龄的增长呈直线增加,而24 h PP随年龄增长呈曲线增加.结论 AASI作为反映血压关系的指标,其在正常人中表现为随年龄增大而增大的变化规律;与传统指标24 h PP相关,提示可作为预测动脉僵硬程度的新指标.
目的 動態動脈僵硬指數(AASI)是新近提齣的反映收縮壓(SBP)和舒張壓(DBP)之間動力學關繫的一項指標,這項研究的主要目的是探討正常人AASI隨年齡的變化及其與24 h脈壓(24 h PP)的相關性.方法 246名正常人[平均年齡(59.7±14.6)歲,女性佔38.6%]在保持日常工作和生活起居的情況下配戴24 h動態血壓鑑測(ABPM)儀,記錄從早晨6:00到晚上22:00每間隔30min和從晚上22:00到第2天早晨6:00每問隔60 min的血壓讀數、心率(HR)、平均動脈壓(MAP)及脈壓(PP),然後按AASI=1-DBP對SBP的迴歸斜率計算每箇箇體的AASI值.結果 AASI隨年齡的增大而增大.在正常人中,AASI的第95百分位數是0.56,其95%預測區間的上界在20～39歲時為0.49,40～59歲時為0.59,60～79歲時為0.69,≥80歲時為0.79.AASI與24 h PP呈正相關(r=0.497,P＜0.01).在正常人中,AASI隨年齡的增長呈直線增加,而24 h PP隨年齡增長呈麯線增加.結論 AASI作為反映血壓關繫的指標,其在正常人中錶現為隨年齡增大而增大的變化規律;與傳統指標24 h PP相關,提示可作為預測動脈僵硬程度的新指標.
목적 동태동맥강경지수(AASI)시신근제출적반영수축압(SBP)화서장압(DBP)지간동역학관계적일항지표,저항연구적주요목적시탐토정상인AASI수년령적변화급기여24 h맥압(24 h PP)적상관성.방법 246명정상인[평균년령(59.7±14.6)세,녀성점38.6%]재보지일상공작화생활기거적정황하배대24 h동태혈압감측(ABPM)의,기록종조신6:00도만상22:00매간격30min화종만상22:00도제2천조신6:00매문격60 min적혈압독수、심솔(HR)、평균동맥압(MAP)급맥압(PP),연후안AASI=1-DBP대SBP적회귀사솔계산매개개체적AASI치.결과 AASI수년령적증대이증대.재정상인중,AASI적제95백분위수시0.56,기95%예측구간적상계재20～39세시위0.49,40～59세시위0.59,60～79세시위0.69,≥80세시위0.79.AASI여24 h PP정정상관(r=0.497,P＜0.01).재정상인중,AASI수년령적증장정직선증가,이24 h PP수년령증장정곡선증가.결론 AASI작위반영혈압관계적지표,기재정상인중표현위수년령증대이증대적변화규률;여전통지표24 h PP상관,제시가작위예측동맥강경정도적신지표.
Objective Ambulatory arterial stiffness index (AASI) has been recently proposed to reflect the dynamic relation between diastolic and systolic blood pressure throughout the whole day. The aim of our study was to investigate the change in AASI with advancing age and the correlation with 24 hours pulse pressure (24 h PP) in healthy individuals. Methods 246 healthy subjects [mean age(59. 7 ±14.6) years, women 38.6% ] underwent 24 hours ambulatory blood pressure monitoring ( ABPM) in normal life style. The blood pressure recordings, heart rate (HR) , mean arterial pressure (MAP) and pulse pressure (PP) were analyzed simultaneously by computer for every 30 minutes during 6:00 am-22:00 pm and every 60 minutes during 22:00 ptn-6:00 am. Using all the blood pressure recordings, we plotted diastolic against systolic blood pressure from each individuals and calculated the regression slope. AASI was derived from 1 minus this regression slope. Results In 246 healthy individuals, AASI increased with age. Among the healthy individuals, the 95th percentile of AASI was 0. 56, the upper boundary of the 95% prediction interval of AASI in relation to age were 0.49 at 20 - 39 years ,0.59 at 40 - 59 years ,0.69 at 60 - 79 years, 0.79 at≥80 years. The correlation coefficient between AASI and 24 h PP was 0.497(P <0. 01 ). AASI linearly increased with age in healthy individuals, whereas the relation between pulse pressure and age was curvilinear. Conclusions AASI as a index reflecting blood pressure relationship, manifested the corresponding change with advancing age. The correlation between AASI and traditional index 24 h PP indicated AASI as a new measure of arterial stiffness.
