CAJ | 학술논문

目的研究灵杆菌多糖对肿瘤生长的抑制作用和对抗免疫抑制的作用.方法建立小鼠荷S-180实体瘤模型,以及环磷酰胺诱导的免疫抑制小鼠模型,观察腹腔注射灵杆菌多糖对肿瘤生长、免疫器官指数、外周白细胞数的影响.结果荷S-180实体瘤小鼠连续8 d腹腔注射灵杆菌多糖40 U/kg对肿瘤生长有显著的抑制作用(P<0.01),并显著地提高荷瘤小鼠的脾脏指数,但对胸腺指数无明显影响.灵杆菌多糖腹腔注射连续7 d,对环磷酰胺所致的免疫低下小鼠的外周血白细胞数和脾指数的降低有显著的对抗作用,对正常小鼠的各指标没有显著性的影响.结论灵杆菌多糖对对荷瘤小鼠和免疫低下小鼠有抑制肿瘤生长.增强免疫功能的作用.
목적 연구령간균다당대종류생장적억제작용화대항면역억제적작용.방법 건립소서하S-180실체류모형,이급배린선알유도적면역억제소서모형,관찰복강주사령간균다당대종류생장、면역기관지수、외주백세포수적영향.결과 하S-180실체류소서련속8 d복강주사령간균다당40 U/kg대종류생장유현저적억제작용(P<0.01),병현저지제고하류소서적비장지수,단대흉선지수무명현영향.령간균다당복강주사련속7 d,대배린선알소치적면역저하소서적외주혈백세포수화비지수적강저유현저적대항작용,대정상소서적각지표몰유현저성적영향.결론 령간균다당대대하류소서화면역저하소서유억제종류생장.증강면역공능적작용.
Objective To observe the effects of lipopolysaccharides of Bacterium prodigiosum (BP-LPS) in inhibiting tumor growth and improving immunosuppression in mice. Methods In mice bearing S180 tumor and a mouse model of immunosuppression induced by cyclophosphamide (CTX), the tumor growth, indexes of the immune organs and peripheral white blood cell count were measured after intraperitoneal injection of BP-LPS. Results Injections of BP-LPS (40 U/kg) for 8 consecutive days resulted in a significant inhibition of the tumor growth in mice bearing S180 tumor (P<0.01), with a dose-dependent increase of the spleen indexes but no obvious changes in the thymus indexes. Intraperitoneal injections of BP-LPS for 7 days inhibited the reduction of peripheral white blood cells and spleen indexes in immunosuppressive mice, but did not produce any significant changes in normal mice. Conclusion BP-LPS can inhibit the tumor growth in tumor-bearing mice and enhance the immune functions of immunosuppressive mice.