CAJ | 학술논문

目的:评价颌下腺移位术预防鼻咽癌放疗后口干燥症的长期效果.方法:70例鼻咽癌患者随机分为试验组36例和对照组34例.试验组在行常规放疗前将颌下腺移位至颏下区,放疗时颏下区设置挡块.~(99)T_c核素扫描检测放疗前后颌下腺功能,测定放疗前后唾液分泌量,放疗后60个月进行口干程度问卷调查,统计5年生存率.结果:放疗后60个月:试验组颌下腺摄取、分泌功能均明显较对照组好,两者之间有显著性差异,P值分别为0.000和0.000;试验组和对照组唾液量的平均值分别为1.65g和0.73g(P=0.000);试验组中度至重度口干燥症的发生率亦显著低于对照组(12.9% vs 78.6%,P=0.000);试验组和对照组的5年生存率分别为86.1%和82.4%,两者之间无显著性差异(P=0.67).结论:颌下腺移位术不影响鼻咽癌远期疗效,预防鼻咽癌放疗后口干燥症的长期效果良好,可改善鼻咽癌患者放疗后的生存质量.
목적:평개합하선이위술예방비인암방료후구간조증적장기효과.방법:70례비인암환자수궤분위시험조36례화대조조34례.시험조재행상규방료전장합하선이위지해하구,방료시해하구설치당괴.~(99)T_c핵소소묘검측방료전후합하선공능,측정방료전후타액분비량,방료후60개월진행구간정도문권조사,통계5년생존솔.결과:방료후60개월:시험조합하선섭취、분비공능균명현교대조조호,량자지간유현저성차이,P치분별위0.000화0.000;시험조화대조조타액량적평균치분별위1.65g화0.73g(P=0.000);시험조중도지중도구간조증적발생솔역현저저우대조조(12.9% vs 78.6%,P=0.000);시험조화대조조적5년생존솔분별위86.1%화82.4%,량자지간무현저성차이(P=0.67).결론:합하선이위술불영향비인암원기료효,예방비인암방료후구간조증적장기효과량호,가개선비인암환자방료후적생존질량.
Objective: To investigate the long-term effect of submandibular salivary gland transfer on xerostomia induced by radiation in patients with nasopharyngeal carcinoma (NPC). Methods: A total of 70 eligible patients with NPC were divided into the test group (36 cases) and the control group (34 cases). In the test group, the submandibular salivary glands were transferred to the submental space before conventional radiotherapy (XRT) and shielded during XRT. Submandibular gland function and salivary fluid before and after radiotherapy, questionnaire of xerostomia at 60 months after XRT, and 5-year survival rate were compared between the two groups. Results: At 5 years after XRT, the trapping and excretion function of submandibular glands were significantly better in the test group (P=0.000 and P=0.000, respectively). The mean weight of saliva after XRT was greater in the test group than in the control group (1.65gvs.0.73g, P=0.000). Incidence of moderate to severe degree of xerostomia was significantly lower in the test group than in the control group (12.9%vs.78.6%, P=0.000). No significant difference was found in 5 year survival rate between the two groups (86.1%vs.82.4%, P＞0.05). Conclusion: Submandibular gland transfer procedure is safe for NPC patients. It can prevent XRT induced xerostomia and improve the quality of life of NPC patients.