检验医学
檢驗醫學
검험의학
LABORATORY MEDICINE
2010年
2期
86-88
,共3页
田国力%朱伟明%王燕敏%许洪平%姚静
田國力%硃偉明%王燕敏%許洪平%姚靜
전국력%주위명%왕연민%허홍평%요정
17-羟孕酮%先天性肾上腺皮质增生症%新生儿疾病筛查
17-羥孕酮%先天性腎上腺皮質增生癥%新生兒疾病篩查
17-간잉동%선천성신상선피질증생증%신생인질병사사
17-hydroxyprogesterone%Congenital adrenal hyperplasia%Neonatal screening
目的 开展新生儿先天性肾上腺皮质增生症(CAH)筛查,降低残疾儿童的发生率,提高人口素质.方法 采用时间分辨荧光免疫分析法检测新生儿滤纸干血片上的17-羟孕酮(17-OHP)浓度.结果 筛查93 971例新生儿,确诊5例,CAH发生率为1/18 795;98.7%的新生儿17-OHP＜40 nmol/L.结论 开展新生儿CAH筛查可以早期诊断和治疗CAH,值得在我国推广.17-OHP的阳性临界值取40 nmol/L是可行的.
目的 開展新生兒先天性腎上腺皮質增生癥(CAH)篩查,降低殘疾兒童的髮生率,提高人口素質.方法 採用時間分辨熒光免疫分析法檢測新生兒濾紙榦血片上的17-羥孕酮(17-OHP)濃度.結果 篩查93 971例新生兒,確診5例,CAH髮生率為1/18 795;98.7%的新生兒17-OHP＜40 nmol/L.結論 開展新生兒CAH篩查可以早期診斷和治療CAH,值得在我國推廣.17-OHP的暘性臨界值取40 nmol/L是可行的.
목적 개전신생인선천성신상선피질증생증(CAH)사사,강저잔질인동적발생솔,제고인구소질.방법 채용시간분변형광면역분석법검측신생인려지간혈편상적17-간잉동(17-OHP)농도.결과 사사93 971례신생인,학진5례,CAH발생솔위1/18 795;98.7%적신생인17-OHP＜40 nmol/L.결론 개전신생인CAH사사가이조기진단화치료CAH,치득재아국추엄.17-OHP적양성림계치취40 nmol/L시가행적.
Objective To develop the neonatal screening for congenital adrenal hyperplasia(CAH)in order to prevent children from congenital disability and improve the aristogenesis in our country. Methods 17-hydroxyprogesterone (17-OHP) of blood samples was measured by time-resolved fluorescence immunoassay in neonates. Results 93 971 neonates were screened .Five were confirmed as 40 nmol/L. Conclusions CAH can be diagnosed and prevented by CAH neonatal screening in neonates which is worth to be extended. It is feasible for the 17-OHP positive cut-off to be 40 nmol/L.
