CAJ | 학술논문

背景与目的:骨转移导致骨质破坏,可引起骨转换标志物(bone turnover markers)水平的改变;因此,本研究旨在探讨骨转换标志物在非小细胞肺癌(non-small cell lung cancer,NSCLC)骨转移诊断及病情评价方面的应用价值.方法:定量检测76例NSCLC骨转移患者血清中碱性磷酸酶(alkaline phosphatase,AKP)、β-Ⅰ型胶原羧基端肽(β-C-terminal telopeptide of type Ⅰ collagen,β-CTx)、骨钙素(osteocalcin,OST)和骨特异性碱性磷酸酶(bone-specific alkaline phosphatase,BALP)水平,并与44例健康人群进行对照.结果:骨转移组患者血清中AKP、β-CTx和BALP水平均明显高于正常对照组.各骨转换标志物之间有很好的相关性,BALP和OST的表达水平与骨转移程度呈正相关性.β-CTx表达水平较高和BALP表达水平较低的患者发生病理性骨折可能性增加.结论:骨代谢标志物在NSCLC骨转移患者诊断及病情判断方面有重要的参考价值,在临床上有广泛的应用前景.
배경여목적:골전이도치골질파배,가인기골전환표지물(bone turnover markers)수평적개변;인차,본연구지재탐토골전환표지물재비소세포폐암(non-small cell lung cancer,NSCLC)골전이진단급병정평개방면적응용개치.방법:정량검측76례NSCLC골전이환자혈청중감성린산매(alkaline phosphatase,AKP)、β-Ⅰ형효원최기단태(β-C-terminal telopeptide of type Ⅰ collagen,β-CTx)、골개소(osteocalcin,OST)화골특이성감성린산매(bone-specific alkaline phosphatase,BALP)수평,병여44례건강인군진행대조.결과:골전이조환자혈청중AKP、β-CTx화BALP수평균명현고우정상대조조.각골전환표지물지간유흔호적상관성,BALP화OST적표체수평여골전이정도정정상관성.β-CTx표체수평교고화BALP표체수평교저적환자발생병이성골절가능성증가.결론:골대사표지물재NSCLC골전이환자진단급병정판단방면유중요적삼고개치,재림상상유엄범적응용전경.
Background and purpose:Bone metastases leads to the destruction of bones by changing the level of bone turnover markers.The purpose of this study was to assess the clinical application value of bone turnover markers in bone metastases for non-small cell lung cancer,which included the diagnosis and spread behavior of bone metastases.Methods:AKP,β-CTx,OST and BALP were measured in 76 NSCLC with bone metastases patients and 44 normal people.Results:The level ofAKP,β-CTx and BALP in patients with bone metastasis was significantly higher than in the subjects without bone metastases.There were significant correlations among the bone turnover markers.The levels of BALP and OST were significantly positively correlated with the extent of bone metastasis.Patients with high-levels of CTx and low-levels of BALP had a higher risk of pathologic fracture.Conclusion:In patients with bone metastases from NSCLC,bone turnover markers can help make diagnoses and evaluate severity of disease.It potentially has a wide range of uses in clinical practice.