CAJ | 학술논문

目的探讨胰岛素样生长因子(insulin-like growth factor,IGF)与系统性硬皮病(systemic sclerosis,SSc)的关系.方法采集2010年至2011年北京协和医院皮肤科就诊的24例SSc患者血清,其中弥漫型SSc 12例,局限型SSc 12例;另外采集12名健康对照者及6例系统性红斑狼疮患者血清,通过ELISA法检测血清IGF系统各因子的表达,并结合患者临床资料进行分析.结果 SSc患者血清IGF-Ⅰ和胰岛素样生长因子结合蛋白(insulin-like growth factor binding protein,IGFBP)-3水平高于健康对照组[分别为(49.21±37.94)ng/ml vs.(15.54±9.07)ng/ml和(3.38±2.09) ng/ml vs.(1.00±0.83) ng/ml,P<0.001],且SSc患者血清IGF-Ⅰ与IGFBP-3水平呈正相关(r=0.883,P<0.001).血清IGF-Ⅰ和IGFBP-3水平与患者年龄、病程、Rodnan皮肤评分不存在相关性.血清IGF-Ⅰ和IGFBP-3水平在Scl-70抗体阳性与阴性SSc患者间及在肺间质纤维化与无肺间质纤维化SSc患者间差异均无统计学意义.SSc患者血清IGF-Ⅱ、IGFBP-5和IGFBP相关蛋白1(IGFBP-related protein 1,IGFBP-rP1)水平与健康对照组比较差异无统计学意义.结论 SSc患者血清IGF-Ⅰ和IGFBP-3水平升高,IGF系统可能参与了SSc的发病机制.
목적 탐토이도소양생장인자(insulin-like growth factor,IGF)여계통성경피병(systemic sclerosis,SSc)적관계.방법 채집2010년지2011년북경협화의원피부과취진적24례SSc환자혈청,기중미만형SSc 12례,국한형SSc 12례;령외채집12명건강대조자급6례계통성홍반랑창환자혈청,통과ELISA법검측혈청IGF계통각인자적표체,병결합환자림상자료진행분석.결과 SSc환자혈청IGF-Ⅰ화이도소양생장인자결합단백(insulin-like growth factor binding protein,IGFBP)-3수평고우건강대조조[분별위(49.21±37.94)ng/ml vs.(15.54±9.07)ng/ml화(3.38±2.09) ng/ml vs.(1.00±0.83) ng/ml,P<0.001],차SSc환자혈청IGF-Ⅰ여IGFBP-3수평정정상관(r=0.883,P<0.001).혈청IGF-Ⅰ화IGFBP-3수평여환자년령、병정、Rodnan피부평분불존재상관성.혈청IGF-Ⅰ화IGFBP-3수평재Scl-70항체양성여음성SSc환자간급재폐간질섬유화여무폐간질섬유화SSc환자간차이균무통계학의의.SSc환자혈청IGF-Ⅱ、IGFBP-5화IGFBP상관단백1(IGFBP-related protein 1,IGFBP-rP1)수평여건강대조조비교차이무통계학의의.결론 SSc환자혈청IGF-Ⅰ화IGFBP-3수평승고,IGF계통가능삼여료SSc적발병궤제.