CAJ | 학술논문

目的研制23价肺炎链球菌荚膜多糖疫苗.方法大罐培养1、2、3、4、5、6B、7F、8、9N、9V、10A、11A、12F、14、15B、17F、18C、19A、19F、20、22F、23F、和33F型肺炎链球菌并进行各型荚膜多糖的纯化,制备23价肺炎链球菌荚膜多糖疫苗.结果经检定各型精制多糖主要质量指标均符合<欧洲药典>(2005年版)要求.结论已建立起成熟的细菌培养和多糖纯化工艺.
목적 연제23개폐염련구균협막다당역묘.방법 대관배양1、2、3、4、5、6B、7F、8、9N、9V、10A、11A、12F、14、15B、17F、18C、19A、19F、20、22F、23F、화33F형폐염련구균병진행각형협막다당적순화,제비23개폐염련구균협막다당역묘.결과 경검정각형정제다당주요질량지표균부합<구주약전>(2005년판)요구.결론 이건립기성숙적세균배양화다당순화공예.
Objective To prepare 23-valent pneumococcal capsular polysaccharide vaccine. Methods Pneumococci types 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23 F and 33 F were cultivated in the large fermenter and various types of capsular polysaccharides were purified to prepare 23-valent pneumococcal capsular polysaccharide vaccine. Results The main quality indices of the various types of purified polysaccharides conformed to the requirements of European Pharmacopoeia (2005). Conclusion The mature processes of bacterial cultivation and polysaccharide purification are established.