CAJ | 학술논문

实体瘤乏氧代谢区的存在,降低了放化疗的治疗效果,成为肿瘤治疗中难以逾越的障碍.基因治疗是肿瘤治疗中最有前途的方法,但目前所使用的基因转移载体的靶向性较差,而厌氧菌具有趋低氧的特点,对实体瘤组织具有良好的靶向性,成为肿瘤基因治疗的转移载体.
실체류핍양대사구적존재,강저료방화료적치료효과,성위종류치료중난이유월적장애.기인치료시종류치료중최유전도적방법,단목전소사용적기인전이재체적파향성교차,이염양균구유추저양적특점,대실체류조직구유량호적파향성,성위종류기인치료적전이재체.
Hypoxic metabolism in solid tumor reduces chemoradiotherapy effect and become the obstacle in tumor therapy. Gene therapy is the most promising tumor treatment method, but currently using carriers cannot target tumors accurately. Anaerobic bacteria has become the transferring carrier in tumor gene therapy because it has tendency to hypoxia in solid tumors and can target solid tumors more accurately.