CAJ | 학술논문

目的研究高脂血症患者内皮功能异常、早期动脉弹性改变及阿托伐他汀对这些改变的影响.方法选择未曾治疗的高脂血症患者40例作为研究组,健康体检者30例为对照组,应用在血管回声跟踪技术(eTRACKING)基础上实现的血流介导血管舒张检测技术(FMD)评估右肱动脉硬化参数及血管舒张参数,包括压力应变弹性系数(Ep)、硬度指数(β)、顺应性(AC)及收缩期血流介导血管舒张( FMDs)、舒张期血流介导血管舒张(FMDd)；研究组给予阿托伐他汀20 mg口服,12周后复查总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及上述参数,并进行统计学分析.结果研究组β、Ep均较对照组明显升高(均P＜0.001),而AC、FMDs、FMDd较对照组明显降低(均P＜0.001)；研究组治疗前后比较:TC、LDL-C、β、Ep降低,AC、FMDs、FMDd升高并有统计学意义(均P＜0.001).结论高脂血症患者在动脉内膜出现异常改变之前已出现内皮功能损伤及血管早期硬化改变,而阿托伐他汀干预能逆转这些改变.
목적 연구고지혈증환자내피공능이상、조기동맥탄성개변급아탁벌타정대저사개변적영향.방법 선택미증치료적고지혈증환자40례작위연구조,건강체검자30례위대조조,응용재혈관회성근종기술(eTRACKING)기출상실현적혈류개도혈관서장검측기술(FMD)평고우굉동맥경화삼수급혈관서장삼수,포괄압력응변탄성계수(Ep)、경도지수(β)、순응성(AC)급수축기혈류개도혈관서장( FMDs)、서장기혈류개도혈관서장(FMDd)；연구조급여아탁벌타정20 mg구복,12주후복사총담고순(TC)、저밀도지단백담고순(LDL-C)급상술삼수,병진행통계학분석.결과 연구조β、Ep균교대조조명현승고(균P＜0.001),이AC、FMDs、FMDd교대조조명현강저(균P＜0.001)；연구조치료전후비교:TC、LDL-C、β、Ep강저,AC、FMDs、FMDd승고병유통계학의의(균P＜0.001).결론 고지혈증환자재동맥내막출현이상개변지전이출현내피공능손상급혈관조기경화개변,이아탁벌타정간예능역전저사개변.
Objective To research the endothelial dysfunction and early changes in arterial elasticity in patients with hyperlipidemia and effects of atorvastatin on these changes.Methods 40 patients with hyperlipidemia but without any treatment in our hospital were selected as a study group,and 30 healthy people were selected as control group.Use the Flow mediated dilation,FMD detection which bases on the echo-trackingtechnology,eTRACYING to evaluate the right brachial atherosclerosis parameters and vascular diastolic parameters,including the pressure strain elastic modulus(Ep) ;stiffness index (β) ;compliance (AC) ;FMDs and FMDd.The study group take atorvastatin 20mg per day,then retested above parameters and TC,LDL-C after 12 weeks and analyzed all parameters.Results The values of β and Ep in study group are significantly higher than the control group (all P ＜ 0.001 ),but AC;FMDs and FMDd are significantly lower than the control group( all P ＜ 0.001 ).The results of the study group after the treatment of atorvastatin are as follwing:TC,LDL-C,β and Ep are lower than before,AC,FMDs and FMDd are higher than before;and the differences are of significance in statistics ( all P ＜ 0.001 ).Conclusion Hyperlipidemic patients had shown the vascular endothelial injury and vascular early hardening before the abnormal changes in intimal,but the atorvastatin intervention could reverse these changes.