中国医药
中國醫藥
중국의약
CHINA MEDICINE
2011年
2期
229-230
,共2页
肠杆菌,阴沟%抗菌药%抗药性
腸桿菌,陰溝%抗菌藥%抗藥性
장간균,음구%항균약%항약성
Enterobacter cloacae%Anti-bacterial agents%Drug resistance
目的 调查阴沟肠杆菌的临床分布及耐药性变化以指导临床抗感染治疗.方法 采用美国Dade MicroScan公司生产的AutoSCAN4半自动鉴定仪和配套的生化反应药敏板及微最稀释法,对287株阴沟肠杆菌进行分离鉴定和药敏试验,并对其分布及耐药情况进行分析.结果 287株阴沟肠杆菌主要标本来源为痰液[146株(50.9%)],科室分布中加强监护病房是主要感染区[58株(20.2%)].阴沟肠杆菌对亚胺培南的耐药率较低(平均耐药率为6.27%),对是哌拉西林/他唑巴坦、阿米卡星、左氧氟沙星的平均耐药率分别是27.91%、34.49%、36.40%,其余抗菌药物耐药率均＞40%.结论 临床上应及时正确治疗严重的基础疾病、严格消毒灭菌、避免或缩短侵入性操作、合理应用抗菌药物和激素,以减少阴沟肠杆菌耐药性的产生和播散.
目的 調查陰溝腸桿菌的臨床分佈及耐藥性變化以指導臨床抗感染治療.方法 採用美國Dade MicroScan公司生產的AutoSCAN4半自動鑒定儀和配套的生化反應藥敏闆及微最稀釋法,對287株陰溝腸桿菌進行分離鑒定和藥敏試驗,併對其分佈及耐藥情況進行分析.結果 287株陰溝腸桿菌主要標本來源為痰液[146株(50.9%)],科室分佈中加彊鑑護病房是主要感染區[58株(20.2%)].陰溝腸桿菌對亞胺培南的耐藥率較低(平均耐藥率為6.27%),對是哌拉西林/他唑巴坦、阿米卡星、左氧氟沙星的平均耐藥率分彆是27.91%、34.49%、36.40%,其餘抗菌藥物耐藥率均＞40%.結論 臨床上應及時正確治療嚴重的基礎疾病、嚴格消毒滅菌、避免或縮短侵入性操作、閤理應用抗菌藥物和激素,以減少陰溝腸桿菌耐藥性的產生和播散.
목적 조사음구장간균적림상분포급내약성변화이지도림상항감염치료.방법 채용미국Dade MicroScan공사생산적AutoSCAN4반자동감정의화배투적생화반응약민판급미최희석법,대287주음구장간균진행분리감정화약민시험,병대기분포급내약정황진행분석.결과 287주음구장간균주요표본래원위담액[146주(50.9%)],과실분포중가강감호병방시주요감염구[58주(20.2%)].음구장간균대아알배남적내약솔교저(평균내약솔위6.27%),대시고랍서림/타서파탄、아미잡성、좌양불사성적평균내약솔분별시27.91%、34.49%、36.40%,기여항균약물내약솔균＞40%.결론 림상상응급시정학치료엄중적기출질병、엄격소독멸균、피면혹축단침입성조작、합리응용항균약물화격소,이감소음구장간균내약성적산생화파산.
Objective To investigate the clinical distribution of enterobacter cloacae and the change in drug resistance,to give instructions on clinical anti-infectious therapy. Methods Two hundreds and eighty-seven enterobacter cloacae were identified,isolated and performed drug sensitive test by using AutoSCAN4 (Dade MicroScan,USA) and the matching drug susceptibility plate. Results One hundred and forty-six enterobacter cloacae (50.9%) were isolated from expectoration specimen,while 58 enterobacter cloacae (20.2%) were isolated from the specimen from ICU. Enterobacter cloacae showed a low drug resistance rate to imipenem (6.27%),followed by piperacillin/tazobactam (27.91%),amikacin (34.49%),and levofloxacin (34.49%). The rates to other anti-biotic drugs were higher than 40%. Conclusions In the process of clinical treatment,in order to reduce the possibility of the enterobacter cloacae and its generation of drug resistance,physicians should treat primary disease,perform sterilization,avoid invasive treatment and choose the drugs reasonably according to the antibiotic susceptibility results.
