CAJ | 학술논문

目的建立适用于动眼神经损伤后神经再生及功能修复电生理研究的动物模型.方法 20只Beagle犬随机均分为单纯损伤组及损伤+刺激组.行右侧动眼神经海绵窦后段压榨损伤、颅内动眼神经刺激电极植入及右侧下斜肌记录电极植入.结果实验手术均被所有实验犬耐受,下斜肌记录电极和颅内刺激电极成功植入,可用于记录运动单位电位(MUPs)及混合肌肉动作电位(CMAPs).结论应用于动眼神经再生修复电生理研究的动物模型已经建立,此模型具有良好的可行性及可重复性.
목적 건립괄용우동안신경손상후신경재생급공능수복전생리연구적동물모형.방법 20지Beagle견수궤균분위단순손상조급손상+자격조.행우측동안신경해면두후단압자손상、로내동안신경자격전겁식입급우측하사기기록전겁식입.결과 실험수술균피소유실험견내수,하사기기록전겁화로내자격전겁성공식입,가용우기록운동단위전위(MUPs)급혼합기육동작전위(CMAPs).결론 응용우동안신경재생수복전생리연구적동물모형이경건립,차모형구유량호적가행성급가중복성.
Objective To establish a feasible and reproducible dog model of oculomotor nerves injury, and to investigate the physiological electric for ocuolomotor nerves regeneration and recovery. Methods Experiment was carried out on 20 normal adult Beagle dogs. All Beagle dogs were distributed equally simplex crush injury and crush plus electrical stimulation groups randomly. Ophthalmic and intracranial operations in Beagle dogs comprised electrode implantation of the right inferior obliquns and simplex crush injury or crush plus electrode implantation of the right oculomotor nerve behind of cavernous sinus. Results All the procedures used in the study were well tolerated by Beagle canines. Electrode implantation of the right inferior obliquus and the right oculomotor nerve behind of cavernous sinus was successful. The compound muscle action potentials (CMAPs) and muscle units potentials (MUPs)were recorded successfully. Conclusion The animal models have been established to study the physiological electric for ocuolomotor nerves regeneration and recovery and have shown great reproductibility and feasibility.