CAJ | 학술논문

目的通过建立青少年暴力犯罪模型,探讨5-羟色胺转运体(serotonin transporter,5-HTT)基因多态性在暴力犯罪评估预测中的作用.方法使用调查量表分析223例暴力组和148名对照组青少年在人格、社会支持、应付方式、冲动性、攻击性和家庭情况等方面的差异.分别比较暴力组和正常对照组5-HTT基因多态位点5-HTTVNTR、5-HTTLPR基因型与等位基因的分布,以观察5-HTT基因多态性与青少年人格、冲动和攻击等分量表的关系.采用逐步Logistic回归建立青少年暴力犯罪预测模型.结果暴力组和对照组在多个分量表之间差异有统计学意义.5-HTT基因两个多态位点基因型与等位基因频率在男性暴力组和对照组之间差异无统计学意义.建立Logistic回归预测模型,将5-HTT基因多态性纳入青少年暴力犯罪行为预测模型后,未见预测正确率显著提高.结论青少年暴力犯罪与社会因素、环境因素等密切相关.5-HTT多态性与青少年暴力犯罪行为可能不存在关联.
목적 통과건립청소년폭력범죄모형,탐토5-간색알전운체(serotonin transporter,5-HTT)기인다태성재폭력범죄평고예측중적작용.방법 사용조사량표분석223례폭력조화148명대조조청소년재인격、사회지지、응부방식、충동성、공격성화가정정황등방면적차이.분별비교폭력조화정상대조조5-HTT기인다태위점5-HTTVNTR、5-HTTLPR기인형여등위기인적분포,이관찰5-HTT기인다태성여청소년인격、충동화공격등분량표적관계.채용축보Logistic회귀건립청소년폭력범죄예측모형.결과 폭력조화대조조재다개분량표지간차이유통계학의의.5-HTT기인량개다태위점기인형여등위기인빈솔재남성폭력조화대조조지간차이무통계학의의.건립Logistic회귀예측모형,장5-HTT기인다태성납입청소년폭력범죄행위예측모형후,미견예측정학솔현저제고.결론 청소년폭력범죄여사회인소、배경인소등밀절상관.5-HTT다태성여청소년폭력범죄행위가능불존재관련.
Objective To establish an adolescent violence crime prediction model,and to assess the value of serotonin transporter (5-HTT)gene polymorphism for the assessment and prediction of violent crime.Methods Investigative tools were used to analyze the difference in personality dimensions,social support,coping styles,aggressiveness,impulsivity,and family condition scale between 223 adolescents with violence behavior and 148 adolescents without violence behavior. The distribution of 5-HTT gene polymorphisms (5-HTTLPR and 5-HTTVNTR) was compared between the two groups.The role of 5-HTT gene polymorphism on adolescent personality,impulsion and aggression scale also was also analyzed.Stepwise logistic regression was used to establish a predictive model for adolescent violent crime.Results Significant difference was found between the violence group and the control group on multiple dimensions of psychology and environment scales.However,no statistical difference was found with regard to the 5-HTT genotypes and alleles between adolescents with violent behaviors and normal controls.The rate of prediction accuracy was not significantly improved when 5-HTT gene polymorphism was taken into the model.Conclusion The violent crime of adolescents was closely related with social and environmental factors.No association was found between 5-HTT polymorphisms and adolescent violence criminal behavior.