中国抗生素杂志
中國抗生素雜誌
중국항생소잡지
CHINESE JOURNAL OF ANTIBIOTICS
2008年
2期
93-96
,共4页
王兆慧%叶辉%杨玉社%武济民%陈凯先%嵇汝运
王兆慧%葉輝%楊玉社%武濟民%陳凱先%嵇汝運
왕조혜%협휘%양옥사%무제민%진개선%혜여운
抗支原体活性%抗细菌活性%最低抑制浓度%司帕沙星%衍生物%YH37
抗支原體活性%抗細菌活性%最低抑製濃度%司帕沙星%衍生物%YH37
항지원체활성%항세균활성%최저억제농도%사파사성%연생물%YH37
Antimycoplasmal activity%Antibacterial activity%Minimum inhibitory concentration%Sparfloxacin%Derivative%YH37
采用微量稀释法测定了5-氨基-1-环丙基-6,8-二氟-1,4-二氢-7-(3-甲基-1-哌嗪基)-4-氧代喹啉-6-羧酸(YH37)对临床分离的人型支原体(Mh)、解脲脲原体(Uu)以及细菌标准菌株的体外敏感性.结果显示,YH37对Mh的抑制活性较强,MIC90为0.25mg/L,是司帕沙星的1/8;对Uu的MIC90为1mg/L,是司帕沙星的1/4.YH37对Mh、Uu的喹诺酮耐药株有一定的抑制活性,其MIC分别为CPLX的1/4～1/16.YH37对被测细菌的抑制活性是左氧氟沙星的1/8～1/16,是司帕沙星的1/2.
採用微量稀釋法測定瞭5-氨基-1-環丙基-6,8-二氟-1,4-二氫-7-(3-甲基-1-哌嗪基)-4-氧代喹啉-6-羧痠(YH37)對臨床分離的人型支原體(Mh)、解脲脲原體(Uu)以及細菌標準菌株的體外敏感性.結果顯示,YH37對Mh的抑製活性較彊,MIC90為0.25mg/L,是司帕沙星的1/8;對Uu的MIC90為1mg/L,是司帕沙星的1/4.YH37對Mh、Uu的喹諾酮耐藥株有一定的抑製活性,其MIC分彆為CPLX的1/4～1/16.YH37對被測細菌的抑製活性是左氧氟沙星的1/8～1/16,是司帕沙星的1/2.
채용미량희석법측정료5-안기-1-배병기-6,8-이불-1,4-이경-7-(3-갑기-1-고진기)-4-양대규람-6-최산(YH37)대림상분리적인형지원체(Mh)、해뇨뇨원체(Uu)이급세균표준균주적체외민감성.결과현시,YH37대Mh적억제활성교강,MIC90위0.25mg/L,시사파사성적1/8;대Uu적MIC90위1mg/L,시사파사성적1/4.YH37대Mh、Uu적규낙동내약주유일정적억제활성,기MIC분별위CPLX적1/4～1/16.YH37대피측세균적억제활성시좌양불사성적1/8～1/16,시사파사성적1/2.
The susceptibilities of mycoplasma and bacteria to the derivative(YH37)of sparfloxacin was determined by microdilution method in vitro.Results showed that the minimum inhibition concentration(MICgo)of YH37 against Mycoplasma hominis(Mh)(0.25mg/L),and Ureaplasma urealyticum(Uu)(1.0rag/L),were 1/8 those of sparfloxacin against Mh,and 1/4 those of sparfloxacin against Uu.YH37 was still highly susceptibility to quinolone-resistant strains of Mh and Uu.Its MICs were 1/4～1/16 of that of ciprofloxacin,respectively.MICs of YH37 for bacteria were 1/8～1/16 of that of levofloxacin and 1/2 of that of sparfloxacin.
