CAJ | 학술논문

猪主要组织相容性复合体又称SLA,即为猪白细胞抗原,其编码基因位于猪的第7号染色体上,是一组紧密连锁、高度多态的基因群,包括多个不同位点,是编码移植抗原,控制免疫细胞各亚群间协同作用的一个基因复合体.它不仅与移植排斥有关,而且广泛参与免疫应答的诱导和调节,在遗传、进化、行为、保护及生态等方面都具有重要的科学意义.就SLA-Ⅱ类区域基因目前的研究现状,对它的位置、分类、功能、多态、表达及应用等方面进行了系统阐述.
저주요조직상용성복합체우칭SLA,즉위저백세포항원,기편마기인위우저적제7호염색체상,시일조긴밀련쇄、고도다태적기인군,포괄다개불동위점,시편마이식항원,공제면역세포각아군간협동작용적일개기인복합체.타불부여이식배척유관,이차엄범삼여면역응답적유도화조절,재유전、진화、행위、보호급생태등방면도구유중요적과학의의.취SLA-Ⅱ류구역기인목전적연구현상,대타적위치、분류、공능、다태、표체급응용등방면진행료계통천술.
The major histocompatibility complex (MHC) of swine is called swine lymphocyte antigen (SLA), which situate in the seventh chromosome of swine. It is a set of closely linked and polymorphic gene cluster and include many different site, and encode transplantation antigen and control synergistic effect among immunologic cell subgroups. MHC associates not only with the transplantation rejection reactions but also with immunological responses in a variety of pathological processes, and having important significance in the fields of inherit, evolution, behavior, conservation and ecosystem. In this paper, according to the research status of SLA-II genes, the position, categorization, function, polymorphism, expresion and application of SLA-II genes were reviewed.