中国肿瘤临床
中國腫瘤臨床
중국종류림상
CHINESE JOURNAL OF CLINICAL ONCOLOGY
2010年
1期
29-31
,共3页
刘美%单可人%何燕%张婷%肖雁%吴昌学%王婵娟%王晓亮%官志忠%任锡麟
劉美%單可人%何燕%張婷%肖雁%吳昌學%王嬋娟%王曉亮%官誌忠%任錫麟
류미%단가인%하연%장정%초안%오창학%왕선연%왕효량%관지충%임석린
乳腺癌%成纤维细胞生长因子受体2基因%单核苷酸多态性
乳腺癌%成纖維細胞生長因子受體2基因%單覈苷痠多態性
유선암%성섬유세포생장인자수체2기인%단핵감산다태성
Breast cancer%Fibroblast growth factor receptor 2 gene%Single nucleotide polymorphism
目的:探讨贵州汉族人群成纤维细胞生长因子受体2(fibroblast growth factor receptor 2,FGFR2)基因单核苷酸多态性与女性乳腺癌易感性之间的相关性.方法:运用聚合酶链反应-序列特异性引物(PCR-SSP)方法分析106例女性乳腺癌患者和116例正常对照女性FGFR2基因内含子5 rs1219648多态性的分布情况.结果:乳腺癌组FGFR2基因单核苷酸多态性位点rs1219648的基因型(TT,TC,CC)频率分别为50.00%、25.47%和24.53%,对照组分别为29.31%、48.28%和22.41%,乳腺癌组与对照组T等位基因频率分别为62.74%和53.45%,C等位基因频率分别为37.26%和46.55%,FGFR2 rs1219648基因型频率及等位基因频率在乳腺癌组与时照组中的分布差异均有统计学意义(P<0.05).结论:FGFR2基因内含子5的单核苷酸位点rs1219648多态性与乳腺癌可能具有相关性.携带FGFR2 rs1219648的TT等位基因型的人群可能更易患乳腺癌.
目的:探討貴州漢族人群成纖維細胞生長因子受體2(fibroblast growth factor receptor 2,FGFR2)基因單覈苷痠多態性與女性乳腺癌易感性之間的相關性.方法:運用聚閤酶鏈反應-序列特異性引物(PCR-SSP)方法分析106例女性乳腺癌患者和116例正常對照女性FGFR2基因內含子5 rs1219648多態性的分佈情況.結果:乳腺癌組FGFR2基因單覈苷痠多態性位點rs1219648的基因型(TT,TC,CC)頻率分彆為50.00%、25.47%和24.53%,對照組分彆為29.31%、48.28%和22.41%,乳腺癌組與對照組T等位基因頻率分彆為62.74%和53.45%,C等位基因頻率分彆為37.26%和46.55%,FGFR2 rs1219648基因型頻率及等位基因頻率在乳腺癌組與時照組中的分佈差異均有統計學意義(P<0.05).結論:FGFR2基因內含子5的單覈苷痠位點rs1219648多態性與乳腺癌可能具有相關性.攜帶FGFR2 rs1219648的TT等位基因型的人群可能更易患乳腺癌.
목적:탐토귀주한족인군성섬유세포생장인자수체2(fibroblast growth factor receptor 2,FGFR2)기인단핵감산다태성여녀성유선암역감성지간적상관성.방법:운용취합매련반응-서렬특이성인물(PCR-SSP)방법분석106례녀성유선암환자화116례정상대조녀성FGFR2기인내함자5 rs1219648다태성적분포정황.결과:유선암조FGFR2기인단핵감산다태성위점rs1219648적기인형(TT,TC,CC)빈솔분별위50.00%、25.47%화24.53%,대조조분별위29.31%、48.28%화22.41%,유선암조여대조조T등위기인빈솔분별위62.74%화53.45%,C등위기인빈솔분별위37.26%화46.55%,FGFR2 rs1219648기인형빈솔급등위기인빈솔재유선암조여시조조중적분포차이균유통계학의의(P<0.05).결론:FGFR2기인내함자5적단핵감산위점rs1219648다태성여유선암가능구유상관성.휴대FGFR2 rs1219648적TT등위기인형적인군가능경역환유선암.
Objective:To investigate the association between polymorphisms of FGFR2 and the susceptibility of breast cancer in Han population in Guizhou province.Methods:Genotyping was performed using PCR-sequence-specific primers(PCR-SSP)in 106 histologically confirmed breast cancer cases and 116 cancer-free controls.Results:The genotype frequencies of rs1219648 TT,TC,and CC were 50%,25.47%.and 24.53% in breast cancer cases and 29.31%,48.28%,and 22.41% in the controls.The gene frequencies of T in breast cancer cases and the controls were 62.74% and 53.45%.respectively.The gene frequencies of C were 37.26% and 46.55%.respectively.The distribution of allele and genotype frequencies of FGFR2 rs1219648 was statistically different between breast cancer cases and the controls(P<0.05).Conclusion:FGFR2 rs1219648 polymorphism influences the susceptibility of breast cancer.TT genotype might serve as a risk factor for breast cancer.
