中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
24期
30-32
,共3页
血液肿瘤%真菌%感染%伏立康唑
血液腫瘤%真菌%感染%伏立康唑
혈액종류%진균%감염%복립강서
Hematologic neoplasms%Fungi%Infection%Voriconazole
目的 观察伏立康唑防治血液系统恶性肿瘤并发侵袭性真菌感染(IFI)的疗效和安全性.方法 76例血液系统恶性肿瘤患者按随机数字表法分为观察组(39例)和对照组(37例),分别给予伏立康唑静脉序贯口服给药和伏立康唑静脉给药,比较两组患者IFI及不良反应发生情况.结果 观察组与对照组IFI确诊率分别为17.9％(7/39)、18.9％(7/37),临床诊断率分别为23.1％(9/39)、27.0％(10/37),拟诊率分别为59.0％( 23/39)、54.1％(20/37),两组比较差异无统计学意义(P＞0.05).观察组与对照组视觉障碍发生率分别为12.8％(5/39)、21.6％(8/37),转氨酶升高发生率分别为12.8％(5/39)、43.2％(16/37),两组比较差异有统计学意义(P＜0.05).结论 伏立康唑防治血液系统恶性肿瘤并发IFI效果好,可降低不良反应发生率,值得临床推广.
目的 觀察伏立康唑防治血液繫統噁性腫瘤併髮侵襲性真菌感染(IFI)的療效和安全性.方法 76例血液繫統噁性腫瘤患者按隨機數字錶法分為觀察組(39例)和對照組(37例),分彆給予伏立康唑靜脈序貫口服給藥和伏立康唑靜脈給藥,比較兩組患者IFI及不良反應髮生情況.結果 觀察組與對照組IFI確診率分彆為17.9％(7/39)、18.9％(7/37),臨床診斷率分彆為23.1％(9/39)、27.0％(10/37),擬診率分彆為59.0％( 23/39)、54.1％(20/37),兩組比較差異無統計學意義(P＞0.05).觀察組與對照組視覺障礙髮生率分彆為12.8％(5/39)、21.6％(8/37),轉氨酶升高髮生率分彆為12.8％(5/39)、43.2％(16/37),兩組比較差異有統計學意義(P＜0.05).結論 伏立康唑防治血液繫統噁性腫瘤併髮IFI效果好,可降低不良反應髮生率,值得臨床推廣.
목적 관찰복립강서방치혈액계통악성종류병발침습성진균감염(IFI)적료효화안전성.방법 76례혈액계통악성종류환자안수궤수자표법분위관찰조(39례)화대조조(37례),분별급여복립강서정맥서관구복급약화복립강서정맥급약,비교량조환자IFI급불량반응발생정황.결과 관찰조여대조조IFI학진솔분별위17.9％(7/39)、18.9％(7/37),림상진단솔분별위23.1％(9/39)、27.0％(10/37),의진솔분별위59.0％( 23/39)、54.1％(20/37),량조비교차이무통계학의의(P＞0.05).관찰조여대조조시각장애발생솔분별위12.8％(5/39)、21.6％(8/37),전안매승고발생솔분별위12.8％(5/39)、43.2％(16/37),량조비교차이유통계학의의(P＜0.05).결론 복립강서방치혈액계통악성종류병발IFI효과호,가강저불량반응발생솔,치득림상추엄.
Objective To study the therapeutic effect and safety of voriconazole prevention and cure on invasive fungal infection (IFI) in patients with hematological malignancy.Methods Seventy-six patients with hematological malignancy were divided into observation group (39 cases) and control group (37 cases) by random digits table.The control group was given voriconazole of intravenous drip.The observation group was given voriconazole of intravenous drip sequence oral administration.The rates of occur IFI and adverse effect were compared between the two groups.Results In observation group and control group,the confirmed diagnose rates were 17.9％(7/39) and 18.9％(7/37),clinical diagnose rates were 23.1％(9/39)and 27.0％ (10/37),para-diagnose rates were 59.0％(23/39) and 54.1％(20/37),there was no significant difference between the two groups(P＞ 0.05).In observation group and control group,the paropsia rates were 12.8％(5/39) and 21.6％(8/37),transaminase elevated rates were 12.8％(5/39) and 43.2％( 16/37),there were significant differences between the two groups(P ＜ 0.05 ).Conclusion The voriconazole of intravenous drip sequence oral administration and intravenous drip has a nice effect to IFI,and intravenous drip sequence oral administration could reduce the adverse effect.
