CAJ | 학술논문

目的探讨大肠癌XRCC1基因表达的临床病理意义.方法免疫组织化学法检测107例大肠癌、25例癌旁黏膜与36例正常大肠黏膜的XRCC1表达,分析其与临床病理特征的关系.结果 XRCC1在大肠癌和癌旁黏膜的阳性表达率分别为87.9%(94/107)和84.0%(21/25),均明显高于正常大肠黏膜[27.8%(10/36)](P=0.000,P=0.000);大肠癌中,XRCC1的阳性表达率在低分化组为44.4%(4/9),明显低于中分化组和高分化组的94.8%(50/58)(P=0.000)和87.5%(35/40)(P=0.015);XRCC1表达与患者性别、年龄、肿瘤发生部位、浸润深度及淋巴转移均无明显相关关系(P＞0.05).结论监测XRCC1表达可能有助于大肠癌的诊断.
목적 탐토대장암XRCC1기인표체적림상병리의의.방법 면역조직화학법검측107례대장암、25례암방점막여36례정상대장점막적XRCC1표체,분석기여림상병리특정적관계.결과 XRCC1재대장암화암방점막적양성표체솔분별위87.9%(94/107)화84.0%(21/25),균명현고우정상대장점막[27.8%(10/36)](P=0.000,P=0.000);대장암중,XRCC1적양성표체솔재저분화조위44.4%(4/9),명현저우중분화조화고분화조적94.8%(50/58)(P=0.000)화87.5%(35/40)(P=0.015);XRCC1표체여환자성별、년령、종류발생부위、침윤심도급림파전이균무명현상관관계(P＞0.05).결론 감측XRCC1표체가능유조우대장암적진단.
Objective To explore the clinicopathological value of X-ray repair cross complementing gene 1(XRCC1) expression in colorectal carcinoma. Methods The XRCC1 gene expression in 107 cases of colorectal carcinomas, 25 cases of adjacent mucosa and 36 cases of normal colorectal mucosa was detected immunohistochemically, and the correlation between the expression and clinicopathological factors was analyzed. Results The positive rates of XRCC1 expression in colorectal carcinoma and adjacent mucosa,87.8 % (94/107) and 84.0 % (21/25) respectively, were significantly higher than that in the normal colorectal mucosa [27.8 %(10/36) (P=0.000, P =0.000)]. In colorectal carcinoma, the positive rate of XRCC1 expression in the group of poor differentiation [44.4 % (4/9)] was significantly lower than that in the groups of moderate and well differentiation [94.8 % (50/58)(P=0.000) and 87.5 %(35/40) (P=0.015)], while the positive rate of XRCC1 expression was not related to sex, age, location, infiltration depth and lymph node metastasis (P ＞0.05). Conclusion The results indicated that XRCC 1 protein can be used as a marker to diagnose colorectal carcinoma.