中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2010年
12期
13-15
,共3页
周宣岩%陶谦%张峰%高振峰%吕凌燕
週宣巖%陶謙%張峰%高振峰%呂凌燕
주선암%도겸%장봉%고진봉%려릉연
儿童%睡眠呼吸暂停,阻塞性%α-肿瘤坏死因子%白介素-6%超敏C-反应蛋白
兒童%睡眠呼吸暫停,阻塞性%α-腫瘤壞死因子%白介素-6%超敏C-反應蛋白
인동%수면호흡잠정,조새성%α-종류배사인자%백개소-6%초민C-반응단백
Child%Sleep apnea,obstructive%Tumor necrosis factor-α%Interleukin-6%High-sensitivity C-reactive protein
目的 观察阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患儿行腺样体扁桃体切除手术前、后血清中炎性因子的变化,并评估手术的影响.方法 将45例行扁桃体腺样体切除术的OSAHS患儿作为治疗组,另选45例性别和年龄等与治疗组相匹配的健康儿童为对照组.用超敏ELISA法检测血清α-肿瘤坏死因子(TNF-α)和白介素-6(IL-6),用胶乳增强免疫比浊法检测血清中超敏C-反应蛋白(hs-CRP).治疗组手术治疗后6个月复查上述指标.结果 治疗组术前血清TNF-α、IL-6和hs-CRP水平均高于对照组(P<0.01);经手术治疗后1年,上述指标均低于术前水平(P<0.01);TNF-α、IL-6和hs-CRP水平与AHI呈正相关,与LSaO2呈负相关.结论 手术治疗可有效逆转OSAHS患儿血中TNF-α、IL-6和Hs-CRP的水平,可以将其作为手术治疗效果的评价指标.
目的 觀察阻塞性睡眠呼吸暫停低通氣綜閤徵(OSAHS)患兒行腺樣體扁桃體切除手術前、後血清中炎性因子的變化,併評估手術的影響.方法 將45例行扁桃體腺樣體切除術的OSAHS患兒作為治療組,另選45例性彆和年齡等與治療組相匹配的健康兒童為對照組.用超敏ELISA法檢測血清α-腫瘤壞死因子(TNF-α)和白介素-6(IL-6),用膠乳增彊免疫比濁法檢測血清中超敏C-反應蛋白(hs-CRP).治療組手術治療後6箇月複查上述指標.結果 治療組術前血清TNF-α、IL-6和hs-CRP水平均高于對照組(P<0.01);經手術治療後1年,上述指標均低于術前水平(P<0.01);TNF-α、IL-6和hs-CRP水平與AHI呈正相關,與LSaO2呈負相關.結論 手術治療可有效逆轉OSAHS患兒血中TNF-α、IL-6和Hs-CRP的水平,可以將其作為手術治療效果的評價指標.
목적 관찰조새성수면호흡잠정저통기종합정(OSAHS)환인행선양체편도체절제수술전、후혈청중염성인자적변화,병평고수술적영향.방법 장45례행편도체선양체절제술적OSAHS환인작위치료조,령선45례성별화년령등여치료조상필배적건강인동위대조조.용초민ELISA법검측혈청α-종류배사인자(TNF-α)화백개소-6(IL-6),용효유증강면역비탁법검측혈청중초민C-반응단백(hs-CRP).치료조수술치료후6개월복사상술지표.결과 치료조술전혈청TNF-α、IL-6화hs-CRP수평균고우대조조(P<0.01);경수술치료후1년,상술지표균저우술전수평(P<0.01);TNF-α、IL-6화hs-CRP수평여AHI정정상관,여LSaO2정부상관.결론 수술치료가유효역전OSAHS환인혈중TNF-α、IL-6화Hs-CRP적수평,가이장기작위수술치료효과적평개지표.
Objective To observe the changes of circulating tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) levels in children with obstructive sleep apnea-hypopnea syndrome (OSAHS) before and after operation,and to assess the effect of surgical treatment on the levels of these inflammatory factors. Methods Forty-five children with OSAHS underwent adenoidectomy and tonsillectomy were selected as OSAHS group and matched for age and sex to 45 health children control group. Serum levels of TNF-α and IL-6 were detected by high sensitivity ELISA. The hs-CRP was measured by latex-enhanced turbidometry. The serum levels of these factors in OSAHS group before operation were compared with those of the control group and OSAHS group 6 months after operation. Results Serum levels of TNF-α, IL-6, and hs-CRP in OSAHS group were higher than those in the control group (P<0.01), and the levels in OSAHS group 6 months after operation were significantly lower than those before operation (P<0.01). All the serum parameters were correlated positively with AHI, and negatively with LSaO2. Conclusions Operative treatment can effectively correct circulating serum levels of TNF-α,IL-6 and hs-CRP in children with OSAHS. The changes of TNF-α,IL-6 and hs-CRP levels can be a valuable measure in treatment follow-up.
