CAJ | 학술논문

儿茶酚胺氧位甲基转移酶将S-腺苷蛋氨酸提供的甲基转移到多巴胺、肾上腺素、去甲肾上腺素等儿茶酚胺类的苯环上,使之降解失活.儿茶酚胺氧位甲基转移酶基因对神经递质代谢途径的参与使其成为很多精神疾病的候选基因.本文对儿茶酚胺氧位甲基转移酶基因遗传多态性与精神疾病的相关性作一综述.
인다분알양위갑기전이매장S-선감단안산제공적갑기전이도다파알、신상선소、거갑신상선소등인다분알류적분배상,사지강해실활.인다분알양위갑기전이매기인대신경체질대사도경적삼여사기성위흔다정신질병적후선기인.본문대인다분알양위갑기전이매기인유전다태성여정신질병적상관성작일종술.
The enzyme catechol-O-methyltransferase (COMT) transfers a methyl group from S-adenosylmethionine to the benzene ring of catecholamines including the neurotransmitters dopamine,epinephrine and norepinephrine. This methylation results in the degradation of catecholamines. The involvement of the COMT gene in the metabolic pathway of these neurotransmitters has made it an attractive candidate gene for many psychiatric disorders. This review focuses on the association between the genetic polymorphisms of COMT gene and psychiatric disorders.