肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2010年
1期
52-54
,共3页
癌,非小细胞肺%血管内皮生长因子类%肿瘤转移
癌,非小細胞肺%血管內皮生長因子類%腫瘤轉移
암,비소세포폐%혈관내피생장인자류%종류전이
Carcinoma,non-small-cell lung Vascular endothelial growth factors%Neoplasm metastasis
目的 研究血管内皮生长因子C(VEGF-C)及VEGF受体-3(VEGFR-3)在人类非小细胞肺癌(NSCLC)组织中的表达,并探讨其与淋巴转移之间的关系.方法 对60例NSCLC患者术后标本行VEGF-C、VEGFR-3免疫组织化学(SP法)检测,计数阳性率,并结合临床和病理资料进行分析.结果 60例NSCLC组织中VEGF-C阳性表达率为68.3%(41/60),VEGFR-3阳性表达率为53.3%(32/60),VEGF-C的表达与肺癌分化程度呈负相关(P=0.004),VEGF-C、VEGFR-3的表达与淋巴结转移呈正相关(P=0.009),肺癌组织中VEGF-C与VEGFR-3的表达亦相关(r=0.27).结论 NSCLC组织中VEGF-C、VEGFR-3的表达与肿瘤细胞的淋巴结转移相关.VEGF-C是促使肿瘤组织内淋巴管形成,促进肺癌淋巴结转移的重要原因.
目的 研究血管內皮生長因子C(VEGF-C)及VEGF受體-3(VEGFR-3)在人類非小細胞肺癌(NSCLC)組織中的錶達,併探討其與淋巴轉移之間的關繫.方法 對60例NSCLC患者術後標本行VEGF-C、VEGFR-3免疫組織化學(SP法)檢測,計數暘性率,併結閤臨床和病理資料進行分析.結果 60例NSCLC組織中VEGF-C暘性錶達率為68.3%(41/60),VEGFR-3暘性錶達率為53.3%(32/60),VEGF-C的錶達與肺癌分化程度呈負相關(P=0.004),VEGF-C、VEGFR-3的錶達與淋巴結轉移呈正相關(P=0.009),肺癌組織中VEGF-C與VEGFR-3的錶達亦相關(r=0.27).結論 NSCLC組織中VEGF-C、VEGFR-3的錶達與腫瘤細胞的淋巴結轉移相關.VEGF-C是促使腫瘤組織內淋巴管形成,促進肺癌淋巴結轉移的重要原因.
목적 연구혈관내피생장인자C(VEGF-C)급VEGF수체-3(VEGFR-3)재인류비소세포폐암(NSCLC)조직중적표체,병탐토기여림파전이지간적관계.방법 대60례NSCLC환자술후표본행VEGF-C、VEGFR-3면역조직화학(SP법)검측,계수양성솔,병결합림상화병리자료진행분석.결과 60례NSCLC조직중VEGF-C양성표체솔위68.3%(41/60),VEGFR-3양성표체솔위53.3%(32/60),VEGF-C적표체여폐암분화정도정부상관(P=0.004),VEGF-C、VEGFR-3적표체여림파결전이정정상관(P=0.009),폐암조직중VEGF-C여VEGFR-3적표체역상관(r=0.27).결론 NSCLC조직중VEGF-C、VEGFR-3적표체여종류세포적림파결전이상관.VEGF-C시촉사종류조직내림파관형성,촉진폐암림파결전이적중요원인.
Objective To study the expression of vascular endothelial growth factor-C (VEGF-C) and VEGF receptor-3 (VEGFR-3) in non-small cell lung cancer (NSCLC), and to explore its relationship with lymph node metastasis. Methods Sixty patients with NSCLC were studied. The expression of VEGF-C and VEGFR-3 was detected by immunohistochemistry in lung cancer samples, and its relationship to clinical and pathological data was analyzed. Results The positive expression rate of VEGF-C in NSCLC tissues was 68.3% (41/60), the expression rate of VEGFR-3 was 53.3% (32/60). The expression of VEGF-C was related with the degree of cell differentiation in lung cancer. Both the expressions of VEGF-C and VEGFR-3 were positively associated with lymph node metastasis. There was a positive correlation between VEGF-C and VEGFR-3 expressions (r=0.27). Conclusion The expressions of VEGF-C and VEGFR-3 are related to lymph node metastasis in NSCLC. VEGF-C may promote intratumoral lymphangiogenesis via VEGFR-3 and lymphatic metastasis.
