CAJ | 학술논문

目的探讨低浓度光敏剂、短时间封包、红光光源的光动力疗法治疗痤疮的临床疗效.方法 30例面部痤疮患者随机、单盲分为两组,1组外敷5%5-氨基酮戊酸(ALA)于右侧面部皮损处,左侧面部外敷安慰剂;另1组外敷5%ALA于左侧面部皮损,右侧面部外敷安慰剂.均采用红光照射全面部,每周1次,共4次.每次随访记录皮损数量、测量皮脂含量和色素指数.同时,记录治疗过程中出现的不良反应.结果治疗结束后的第2周,试验侧25.9%的患者皮损改善达到60%以上,而对照侧的皮损改善均低于60%.疗效分析显示,试验侧的疗效要优于对照侧(P<0.05).试验侧的所有皮损计数,包括粉刺、丘疹、脓疱、囊肿,结节及总计数,与基线比较皮损的计数都减少(P<0.05).而对照侧,只有脓疱和总计数与基线比较计数减少(P<0.05).结论 5%ALA-PDT和单用红光治疗痤疮都能使皮损有不同程度的减少,但5%ALA-PDT疗效优于单用红光,不良反应较轻.
목적 탐토저농도광민제、단시간봉포、홍광광원적광동력요법치료좌창적림상료효.방법 30례면부좌창환자수궤、단맹분위량조,1조외부5%5-안기동무산(ALA)우우측면부피손처,좌측면부외부안위제;령1조외부5%ALA우좌측면부피손,우측면부외부안위제.균채용홍광조사전면부,매주1차,공4차.매차수방기록피손수량、측량피지함량화색소지수.동시,기록치료과정중출현적불량반응.결과 치료결속후적제2주,시험측25.9%적환자피손개선체도60%이상,이대조측적피손개선균저우60%.료효분석현시,시험측적료효요우우대조측(P<0.05).시험측적소유피손계수,포괄분자、구진、농포、낭종,결절급총계수,여기선비교피손적계수도감소(P<0.05).이대조측,지유농포화총계수여기선비교계수감소(P<0.05).결론 5%ALA-PDT화단용홍광치료좌창도능사피손유불동정도적감소,단5%ALA-PDT료효우우단용홍광,불량반응교경.
Objective To investigate the clinical efficacy of photodynamic therapy using low concentration of photosensitizer, short incubation time and red light source in the treatment of ache. Methods Thirty patients with facial ache were equally randomized into two groups, one group applying 5% 5-aminolevulinic acid (ALA) to the facial lesions on the right side and placebo agent on the left side as control, the other applying the same concentration of ALA to the facial lesions on the left side and placebo agent on the right side as control. The whole face of every subject was irradiated with red light once a week for 4 sessions. The lesions were counted by a dermatologist, sebum production was measured by a sebum meter (SHP88) and pigmentation index by Mexameter MX 18, at the baseline and on week 2, 4, 8 after the last treatment. Adverse effects were also recorded at each visit. Results Two weeks after the last treatment, a sixty percent or more clinical improvement was achieved in the ALA-treated side of 25.9% patients, but no patients experienced sixty or more percent clinical improvement in control side, and the efficacy of ALA was superior to that of the placebo (P<0.05). A significant reduction was noticed in the count of every kind of lesions, including comedo, papules, pustules, cysts/nodules, as well as the total count of these lesions compared with the baseline (all P<0.05); meanwhile, only the pustule count and total count of lesions were decreased in the control side (both P<0.05). Conclusions Both ALA (5%)-PDT and red light-irradiation alone can reduce the number of acne lesions, but the former is more effective than the latter with few side reactions.