CAJ | 학술논문

目的分析精神病未治疗期(duration of untreated psychosis,DUP)对精神分裂症患者局部脑灰质结构的影响.方法 39例首发未服药精神分裂症患者根据DUP分为长DUP组和短DUP组.所有受试者接受T1加权成像扫描.所得图像经MRIcro软件转化为统计参数图(Statistical Parametric Mapping-V,SPM5)软件町以处理的图像.然后以SPM5软件进行}冬{像的标准化、分割、调整和平滑等步骤.对两组的平滑后灰质图像以VBM方法进行两样本t检验.结果 ①长DUP患者左侧丘脑区(MNI:-6,-16,2;cluster=141voxels)、左侧颞叶区(MNI:-46,-58,-6;cluster=69 voxels)灰质体积较短DUP患者下降.②未发现长DUP患者有脑区灰质体积较短DUP患者增高.结论发病后未治疗时间的延长会加重精神分裂症患者的脑灰质结构障碍.
목적 분석정신병미치료기(duration of untreated psychosis,DUP)대정신분렬증환자국부뇌회질결구적영향.방법 39례수발미복약정신분렬증환자근거DUP분위장DUP조화단DUP조.소유수시자접수T1가권성상소묘.소득도상경MRIcro연건전화위통계삼수도(Statistical Parametric Mapping-V,SPM5)연건정이처리적도상.연후이SPM5연건진행}동{상적표준화、분할、조정화평활등보취.대량조적평활후회질도상이VBM방법진행량양본t검험.결과 ①장DUP환자좌측구뇌구(MNI:-6,-16,2;cluster=141voxels)、좌측섭협구(MNI:-46,-58,-6;cluster=69 voxels)회질체적교단DUP환자하강.②미발현장DUP환자유뇌구회질체적교단DUP환자증고.결론 발병후미치료시간적연장회가중정신분렬증환자적뇌회질결구장애.
Objective To investigate the association of duration of untreated psychosis(DUP) and the gray matter volumes in patients with first-episode schizophrenia.Methods 39 patients with first-episode schizophrenia were divided into two groups according to DUP:long-DUP group and short-DUP group.All the subjects underwent T1 weighted magnetic resonance imaging.After transformed with MRIcro software,all the images underwent standardization,segmentation,modulation and smoothing with Statistical Parametric Mapping 5 (SPM5) software.The gray matter volumes of the two groups underwent two-sample t-test with a Voxel-based morphometry (VBM)using SPM5 software.Results Long-DUP schizophrenic patients presented significantly reduced GM volume in the left thalamus(MNI:-6,-16,2;cluster=141 voxels)and the left temporal lobe(MNI:-46,-58,-6;cluster=69 Voxels),compared with short-DUP schizophrenic patients.Conclusion Delayed DUP may increase the loss of gray matter in schizophrenia.