中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2010年
4期
206-210
,共5页
司天梅%舒良%于欣%马崔%王高华%白培深%刘协和%孙立忠%师建国%陈宪生%梅其一%栗克清
司天梅%舒良%于訢%馬崔%王高華%白培深%劉協和%孫立忠%師建國%陳憲生%梅其一%慄剋清
사천매%서량%우흔%마최%왕고화%백배심%류협화%손립충%사건국%진헌생%매기일%률극청
抑郁%抽样研究%抗抑郁药%处方%药物
抑鬱%抽樣研究%抗抑鬱藥%處方%藥物
억욱%추양연구%항억욱약%처방%약물
Depression%Sampling studies%Antidepressive agents%Prescriptions,drug
目的 调查2006年我国10省市抑郁障碍患者药物治疗现况.方法 按照经济发展水平进行分层和方便取样方法,选择10省市41所精神疾病专科医院或综合医院精神科的1354例抑郁障碍门诊和住院患者,于2006年5月22-28日使用自制修订的调查问卷进行调查.结果 (1)1354例患者中,门诊患者921例(68.0%),住院患者433例(32.0%);男473例(34.9%),女873例(64.5%),缺失8例(0.6%).(2)1281例(94.6%)患者接受抗抑郁药治疗,其中798例(62.3%)患者使用选择性5-HT再摄取抑制剂(SSRIs)治疗,以单一治疗为主(792例,99.2%),使用频率前7位的药物依次为:帕罗西汀312例(24.4%),氟西汀260例(20.3%),文拉法辛250例(19.5%),西酞普兰141例(11.0%),舍曲林81例(6.3%)、米氮平53例(4.1%);219例(17.1%)患者使用三环类药物治疗.(3)590例(43.6%)患者使用苯二氮革类药物治疗,281例(20.8%)患者使用抗精神病药,88例(6.5%)患者使用心境稳定剂;住院患者合并苯二氮革类药物的比例显著高于门诊患者(P＜0.05),急性治疗期合并苯二氮革类药物的比例显著高于稳定治疗期(P＜0.01).结论 新型抗抑郁药已经成为我国治疗抑郁障碍的主要药物,反映出目前抗抑郁药的发展趋势及抑郁障碍治疗理念的更新.
目的 調查2006年我國10省市抑鬱障礙患者藥物治療現況.方法 按照經濟髮展水平進行分層和方便取樣方法,選擇10省市41所精神疾病專科醫院或綜閤醫院精神科的1354例抑鬱障礙門診和住院患者,于2006年5月22-28日使用自製脩訂的調查問捲進行調查.結果 (1)1354例患者中,門診患者921例(68.0%),住院患者433例(32.0%);男473例(34.9%),女873例(64.5%),缺失8例(0.6%).(2)1281例(94.6%)患者接受抗抑鬱藥治療,其中798例(62.3%)患者使用選擇性5-HT再攝取抑製劑(SSRIs)治療,以單一治療為主(792例,99.2%),使用頻率前7位的藥物依次為:帕囉西汀312例(24.4%),氟西汀260例(20.3%),文拉法辛250例(19.5%),西酞普蘭141例(11.0%),捨麯林81例(6.3%)、米氮平53例(4.1%);219例(17.1%)患者使用三環類藥物治療.(3)590例(43.6%)患者使用苯二氮革類藥物治療,281例(20.8%)患者使用抗精神病藥,88例(6.5%)患者使用心境穩定劑;住院患者閤併苯二氮革類藥物的比例顯著高于門診患者(P＜0.05),急性治療期閤併苯二氮革類藥物的比例顯著高于穩定治療期(P＜0.01).結論 新型抗抑鬱藥已經成為我國治療抑鬱障礙的主要藥物,反映齣目前抗抑鬱藥的髮展趨勢及抑鬱障礙治療理唸的更新.
목적 조사2006년아국10성시억욱장애환자약물치료현황.방법 안조경제발전수평진행분층화방편취양방법,선택10성시41소정신질병전과의원혹종합의원정신과적1354례억욱장애문진화주원환자,우2006년5월22-28일사용자제수정적조사문권진행조사.결과 (1)1354례환자중,문진환자921례(68.0%),주원환자433례(32.0%);남473례(34.9%),녀873례(64.5%),결실8례(0.6%).(2)1281례(94.6%)환자접수항억욱약치료,기중798례(62.3%)환자사용선택성5-HT재섭취억제제(SSRIs)치료,이단일치료위주(792례,99.2%),사용빈솔전7위적약물의차위:파라서정312례(24.4%),불서정260례(20.3%),문랍법신250례(19.5%),서태보란141례(11.0%),사곡림81례(6.3%)、미담평53례(4.1%);219례(17.1%)환자사용삼배류약물치료.(3)590례(43.6%)환자사용분이담혁류약물치료,281례(20.8%)환자사용항정신병약,88례(6.5%)환자사용심경은정제;주원환자합병분이담혁류약물적비례현저고우문진환자(P＜0.05),급성치료기합병분이담혁류약물적비례현저고우은정치료기(P＜0.01).결론 신형항억욱약이경성위아국치료억욱장애적주요약물,반영출목전항억욱약적발전추세급억욱장애치료이념적경신.
Objective To uncover the antidepressants drug use patterns for treating depression in China in 2006, and the developing tendency for past 4 years. Methods Based on economic levels in different provinces and the convenient sampling, totally 41 hospitals from 10 provinces and cities were selected out. The investigation was conducted during May 22th -28th, 2006, using the revised self-made questionnaire. Results The total number of the sample was 1354, including outpatients (68.0% ) and with pharmacotherapy, and the antidepressants most frequently prescribed were paroxetine (24.4% of the 1354 patients), fluoxetine (20.3% ), venlafaxine (19.5%), citalopram (11.0%), sertraline (6.3% ),and mirtazapine (4.1% ), while 219 patients ( 17.1% ) were treated with TCAs. 62.3% of patients were treated with SSRIs, and most of them administered monotherapy. The frequency of benzodiazepine,antipsychotics and mood stabilizers used were 43.6%, 20.8% and 6.5%, respectively. Comparing to the outpatients, the frequency to use the benzodiazepine and antipsychotics for the inpatients was higher (P ＜ 0.05). And more patients in acute phase used benzodiazepine than those who were in maintenance phase (P ＜ 0.01 ). Conclusion Novel antidepressants are the mainstream to treat patients with depression in China, the tendency of antidepressants prescription pattern matches the development of treatment outcome and treatment techniques for depression.
