CAJ | 학술논문

目的探讨浅表淋巴结肿大的HIV/AIDS患者的淋巴结病理类型及其特点.方法取浅表淋巴结肿大的151例HIV/AIDS患者的淋巴结组织进行病理学检查,通过HE、抗酸、过碘酸雪夫和淀粉酶消化后过碘酸雪夫染色,光学显微镜下观察,描述和分析其病理结果及其与CD4+T淋巴细胞计数的关系.数据行卡方检验.结果在151例HIV/AIDS患者的淋巴结病理结果中,表现为良性病变的有145例,占96.0%,表现为恶性肿瘤的有6例,占4.0%,其中结核病72例,淋巴结反应性增生34例,淋巴真菌感染23例(其中青霉病19例),AIDS相关淋巴结病14例,非霍奇金淋巴瘤5例,良性纤维组织细胞病1例,结核伴发真菌感染1例,间叶性恶性肿瘤1例.在所有患者中,CD4+T淋巴细胞计数<100×106/L的有83例,占55.0%.青霉病随着CD4+T淋巴细胞计数的减少,发病率明显升高(x2=7.757,P=0.021).结论 HIV/AIDS患者浅表淋巴结肿大的原因大多数为感染性疾病,主要为结核病及真菌感染,且多数发生在CD4+T淋巴细胞计数低下的患者,最常见的恶性肿瘤为非霍奇金淋巴瘤.
목적 탐토천표림파결종대적HIV/AIDS환자적림파결병리류형급기특점.방법 취천표림파결종대적151례HIV/AIDS환자적림파결조직진행병이학검사,통과HE、항산、과전산설부화정분매소화후과전산설부염색,광학현미경하관찰,묘술화분석기병리결과급기여CD4+T림파세포계수적관계.수거행잡방검험.결과 재151례HIV/AIDS환자적림파결병리결과중,표현위량성병변적유145례,점96.0%,표현위악성종류적유6례,점4.0%,기중결핵병72례,림파결반응성증생34례,림파진균감염23례(기중청매병19례),AIDS상관림파결병14례,비곽기금림파류5례,량성섬유조직세포병1례,결핵반발진균감염1례,간협성악성종류1례.재소유환자중,CD4+T림파세포계수<100×106/L적유83례,점55.0%.청매병수착CD4+T림파세포계수적감소,발병솔명현승고(x2=7.757,P=0.021).결론 HIV/AIDS환자천표림파결종대적원인대다수위감염성질병,주요위결핵병급진균감염,차다수발생재CD4+T림파세포계수저하적환자,최상견적악성종류위비곽기금림파류.
Objective To investigate the pathological types and features of lymph nodes in human immunodeficiency virus(HIV)/acquired immune deficiency syndrome(AIDS)patients with superficial lymphadenectasis.Methods The tissues of lymph nodes were obtained from 151 HIV/AIDS patients with superficial lymphadenectasis for pathological examination.The pathological results were observed by light microscope after Hematoxylin-Eosin(HE),acid-fast,periodic acid-Schiff (PAS),and digested-PAS(D-PAS)staining.The pathological results of lymph nodes were described and the correlation between pathological changes and CD4+T lymphocyte count was analyzed.Chisquare test was used for the statistic analysis.Results The benign lesions were found in 145 patients (96.0%),while the malignant tumors were found in 6 patients(4.0%).The pathological findings in the 151 HIV/AIDS patients included tuberculosis(72 patients),lymph node reactive hyperplasia(34patients),lymphatic fungal infections(23 patients,including penicillium diseases in 19 cases),AIDSrelated lymphadenectasis(14 cases),non-Hodgkin lymphoma(5 cases),benign fibrous histiocytoma (1 case).In addition,there were 83 patients(55.0%)with CD4+T lymphocyte count lower than 100×106/L.The frequency of penicillium diseases was higher in patients with lower CD4+T lymphocyte count(x2=7.757,P=0.021).Conclusions The major reasons for superficial lymphadenectasis in HIV/AIDS patients are infectious diseases,such as tuberculosis and fungal infections,which are common in patients with lower CD4+T lymphocyte counts.Non-Hodgkin lymphoma is the most common malignant tumor in this patient population.