CAJ | 학술논문

以苯硫酚为起始原料,与对氟苯甲醛进行取代反应得4-苯硫基苯甲醛（Ⅱ）,再经硼氢化钠还原、浓盐酸氯代两步反应得到目标产物4-苯硫基氯苄（Ⅰ）,总收率88%（以苯硫酚计）,纯度95.8%（高压液相色谱法）.目标化合物结构经核磁共振氢谱、质谱确证.
이분류분위기시원료,여대불분갑철진행취대반응득4-분류기분갑철（Ⅱ）,재경붕경화납환원、농염산록대량보반응득도목표산물4-분류기록변（Ⅰ）,총수솔88%（이분류분계）,순도95.8%（고압액상색보법）.목표화합물결구경핵자공진경보、질보학증.
4-Phenylthiobenzyl chloride was prepared by the substitution of 4-fluorobenzaldehyde with thiophenol to obtain 4-（phenylthio）benzaldehyde,and then reducted with sodium borohydride and chlorination with concentrated hydrochloric acid in an overall yield of 88 %（based on thiophenol）.The purity was 95.8 %.The structure and purity of target product were confirmed by HPLC,1H-NMR and MS.