CAJ | 학술논문

为了解腹腔镜手术对犬肝肾功能变化的影响以及探讨其可能的发生机制.12只健康杂种犬随机均分为两组:胸腔通路腹腔镜膈肌破裂修补术(LDT)和腹腔通路腹腔镜膈肌破裂修补术(LDC).在术前、术后即刻、1、3、5、7 d采集血清样品进行肝肾功能的检测.结果表明,LDT、LDC两组的血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、肌酐(Cr)、尿素(BUN)与术前比较,都有显著性差异(P<0.05).与LDT组比较,LDC组ALT在术后即刻与第3天均有极显著性差异(P<0.01),AST在术后即刻与第1、3天比较均有极显著性差异(P<0.01).同时也对其他肝肾功能指标进行了检测与数据处理,未发现有意义的改变.LDT和LDC可导致血清肝脏、肾脏酶学有统计学意义的短暂增高.LDC较LDT对ALT与AST影响更显著.
위료해복강경수술대견간신공능변화적영향이급탐토기가능적발생궤제.12지건강잡충견수궤균분위량조:흉강통로복강경격기파렬수보술(LDT)화복강통로복강경격기파렬수보술(LDC).재술전、술후즉각、1、3、5、7 d채집혈청양품진행간신공능적검측.결과표명,LDT、LDC량조적혈청곡병전안매(ALT)、곡초전안매(AST)、감성린산매(ALP)、기항(Cr)、뇨소(BUN)여술전비교,도유현저성차이(P<0.05).여LDT조비교,LDC조ALT재술후즉각여제3천균유겁현저성차이(P<0.01),AST재술후즉각여제1、3천비교균유겁현저성차이(P<0.01).동시야대기타간신공능지표진행료검측여수거처리,미발현유의의적개변.LDT화LDC가도치혈청간장、신장매학유통계학의의적단잠증고.LDC교LDT대ALT여AST영향경현저.
Investigate the effect of laparoseopic surgery on the change of hepatic and renal function of dogs, and explore their possible mechanism. Twelve healthy mongrel dogs were randomly divided into two groups: Laparoscopic repair of diaphragmatic rupture through thoracic path in dogs (LDT) and Laparoscopic repair of diaphragmatic rupture through celiac path in dogs (LDC). The venous blood samples were obtained at the time of the preoperative day and immediately, 1, 3, 5, 7 d after operations. The results showed that alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline pho-sphatase (ALP), creatinine (Cr) and blood urea nitrogen (BUN) in group LDT and LDC were significantly increased after operation.These changes occurred in each group that had demonstrated remarkable difference before and after the operation (P<0.05). The degree in the changes of ALT between LDC and LDT was significant (P<0.01) on immediately and 3 d after operations. The differences between LDT and LDC also show significance (P<0.01) on immediately and 1, 3 d after operations. In the mean time, changes of ALP, Cr and BUN before or after surgery in both groups showed no significant difference (P>0.05). Transient elevation of serum liver and renal enzymes can step-up after LDT and LDC on short term. Compared with LDT, the degree in the changes of ALT and AST in LDC was more significant.