CAJ | 학술논문

目的探讨Apelin-12与高血压、肥胖、胰岛素抵抗、炎症等的相关性.方法测定31例单纯2型糖尿病、37例2型糖尿病合并高血压患者及25例健康对照者血浆Apelin-12、肿瘤坏死因子α(TNF-α)、血脂、糖化血红蛋白(HbA1c)、空腹血糖、空腹胰岛素(FINS)、胰岛素抵抗(IR)指数(HOMA-IR)、体重指数(BMI)、血压等水平并进行各参数之间的相关分析.结果 ①糖尿病合并高血压组血浆Apelin-12水平低于正常对照组和单纯糖尿病组(P<0.05或P<0.01),单纯糖尿病组血浆Apelin-12水平高于正常对照组(P<0.05).②糖尿病合并高血压组TNF-α水平高于糖尿病组和正常对照组(P<0.05或P<0.01),糖尿病组TNF-α水平高于正常对照组(P<0.05)③直线相关分析显示,空腹血浆Apelin-12与腰臀比(WHR),FINS,HOMA-IR,甘油三酯(TG),收缩压(SBP),TNF-α呈负相关,与HDL-C呈正相关.结论血浆Apelin-12水平在糖尿病组升高,在糖尿病合并高血压组降低,且与肥胖、IR、炎症等相关.推测Apelin-12可能参与了IR、2型糖尿病、高血压等疾病的发生发展.
목적 탐토Apelin-12여고혈압、비반、이도소저항、염증등적상관성.방법 측정31례단순2형당뇨병、37례2형당뇨병합병고혈압환자급25례건강대조자혈장Apelin-12、종류배사인자α(TNF-α)、혈지、당화혈홍단백(HbA1c)、공복혈당、공복이도소(FINS)、이도소저항(IR)지수(HOMA-IR)、체중지수(BMI)、혈압등수평병진행각삼수지간적상관분석.결과 ①당뇨병합병고혈압조혈장Apelin-12수평저우정상대조조화단순당뇨병조(P<0.05혹P<0.01),단순당뇨병조혈장Apelin-12수평고우정상대조조(P<0.05).②당뇨병합병고혈압조TNF-α수평고우당뇨병조화정상대조조(P<0.05혹P<0.01),당뇨병조TNF-α수평고우정상대조조(P<0.05)③직선상관분석현시,공복혈장Apelin-12여요둔비(WHR),FINS,HOMA-IR,감유삼지(TG),수축압(SBP),TNF-α정부상관,여HDL-C정정상관.결론 혈장Apelin-12수평재당뇨병조승고,재당뇨병합병고혈압조강저,차여비반、IR、염증등상관.추측Apelin-12가능삼여료IR、2형당뇨병、고혈압등질병적발생발전.
Objective To investigate the relationship between plasma apelin-12 level and hypertension, obesity, insulin resistance(IR), inflammation of type 2 diabetes mellitus(T2DM). Methods 25 healthy subjects of control group, 30 T2DM patients, 38 patients with T2DM and hypertension were selected. The plasma levels of apelin-12, tumor necrosis factor-α(TNF-α), blood fat, glycosylated hemoglobin(HbA1c), fasting plasma glucose, fasting insulin level, IR index(HOMA-IR), body mass index(BMI) and blood pressure were measured in each group. Data were analyzed by variable correlation. Results ① The apelin-12 levels in patients with T2DM and hypertension were significantly lower than that in control and T2DM groups(P＜0.05 or P＜0.01),the apelin-12 level of patients with T2DM group was higher than that in control group (P＜0.05).②TNF-α levels in patients with T2DM and hypertension was significantly higher than that in control and T2DM groups(P＜0.05 or P＜0.01),TNF-α level of patients with T2DM only was significantly higher than that in control group(P＜0.05).③There were negative correlation between the plasma apelin-12 level and WHR, FINS, HOMA-IR, TG, SBP, TNF-α,and positive correlation between it and the HDL-C. WHR, HOMA-IR, TG, TNF-α were equal predicators of plasma apelin-12 level. Conclusions The plasma level of apelin-12 is increased in T2DM group and decreased in T2DM with hypertension group.Apelin-12 is correlated with obesity,IR and inflammation. A speculation can be drew that the apelin-12 may contribute to the development of IR, T2DM and hypertension.