CAJ | 학술논문

由于金纳米粒子(AuNPs)具有与大小、形状和聚集程度相关的物理和化学特性,被广泛应用于各种生物分析和生物医学检测技术中,并发展成具有高选择性、高灵敏度的生物分析检测手段.以AuNPs为探针的分析方法通常具有简单、快速、灵敏度高的优点,并能应用于实际样品检测.本文综述了目前生物分子修饰的AuNPs探针的合成及其在检测金属离子、小分子、DNA、蛋白质和细胞内分析等方面的应用.
유우금납미입자(AuNPs)구유여대소、형상화취집정도상관적물리화화학특성,피엄범응용우각충생물분석화생물의학검측기술중,병발전성구유고선택성、고령민도적생물분석검측수단.이AuNPs위탐침적분석방법통상구유간단、쾌속、령민도고적우점,병능응용우실제양품검측.본문종술료목전생물분자수식적AuNPs탐침적합성급기재검측금속리자、소분자、DNA、단백질화세포내분석등방면적응용.
During last decade, gold nanoparticled (AuNPs)-based assays have been well-developed and widely used in biological analysis and biomedical detection because AuNPs have unique physical and chemical properties which depend on the size, shape and degree of aggregation.The AuNPs-based assays have already been employed for detecting practical samples with high simplicity and selectivity.This review discusses the recently development of the synthesis and biological molecular functionalisation of AuNPs and their applications on the heavy metallic cations, small organic compounds, nucleic acids and proteins detection and cellular analysis.